Abstract
Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17- estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.
Keywords: genistein, estrogens, estrogen receptor, signaling, breast cancer
Mini-Reviews in Medicinal Chemistry
Title: Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells
Volume: 6 Issue: 3
Author(s): O. C. Kousidou, G. N. Tzanakakis and N. K. Karamanos
Affiliation:
Keywords: genistein, estrogens, estrogen receptor, signaling, breast cancer
Abstract: Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17- estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.
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Cite this article as:
Kousidou C. O., Tzanakakis N. G. and Karamanos K. N., Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073420
DOI https://dx.doi.org/10.2174/138955706776073420 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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