Abstract
Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular, and peripheral artery disease. Cardiovascular disease (CVD) could account for disabilities and high mortality rates in patients with diabetes. In this paper, we review the molecular mechanisms for accelerated atherosclerosis in diabetes, especially focusing on postprandial hyperglycemia, advanced glycation end products (AGEs) and the renin-angiotensin system. We also discuss here the potential therapeutic strategy that specifically targets CVD in patients with diabetes.
Keywords: AGEs, atherosclerosis, diabetes, oxidative stress, renin-angiotensin system
Mini-Reviews in Medicinal Chemistry
Title: Cardiovascular Disease in Diabetes
Volume: 6 Issue: 3
Author(s): Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Katsuhiko Takenaka, Yuko Jinnouchi and Tsutomu Imaizumi
Affiliation:
Keywords: AGEs, atherosclerosis, diabetes, oxidative stress, renin-angiotensin system
Abstract: Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular, and peripheral artery disease. Cardiovascular disease (CVD) could account for disabilities and high mortality rates in patients with diabetes. In this paper, we review the molecular mechanisms for accelerated atherosclerosis in diabetes, especially focusing on postprandial hyperglycemia, advanced glycation end products (AGEs) and the renin-angiotensin system. We also discuss here the potential therapeutic strategy that specifically targets CVD in patients with diabetes.
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Cite this article as:
Yamagishi Sho-ichi, Nakamura Kazuo, Matsui Takanori, Takenaka Katsuhiko, Jinnouchi Yuko and Imaizumi Tsutomu, Cardiovascular Disease in Diabetes, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073501
DOI https://dx.doi.org/10.2174/138955706776073501 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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