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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Microcystin Produces Disparate Effects on Liver Cells in a Dose Dependent Manner

Author(s): Lars Herfindal and Frode Selheim

Volume 6, Issue 3, 2006

Page: [279 - 285] Pages: 7

DOI: 10.2174/138955706776073475

Price: $65

Abstract

In this review we present recent studies on the effects of the protein phosphatase inhibitor microcystin on mammalian cells. Whereas high concentrations of microcystin promote liver cell death induced by ROS signalling without the involvement of typical apoptotic proteins, intermediate doses activate classic apoptotic pathways. Low concentrations however, increase liver cell survival and proliferation, and can cause primary liver cancer.

Keywords: Microcystin, protein phosphatases, PP1, PP2A, reactive oxygen species, cancer, apoptosis, mitochondria


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