Preparation of a Cyclodextrin Conjugated With Two Arbutin Moieties as a Drug-Carrier Model, and its High Ability for the Inclusion of Doxorubicin

Title: Preparation of a Cyclodextrin Conjugated With Two Arbutin Moieties as a Drug-Carrier Model, and its High Ability for the Inclusion of Doxorubicin

Volume: 3 Issue: 3

Author(s): Takashi Yamanoi, Natsumi Kobayashi, Keiko Takahashi and Kenjiro Hattori

Affiliation:

Keywords: Cyclodextrin, drug-delivery system, drug carrier, stacking effect, arbutin, doxorubicin

Abstract: Cyclodextrin derivatives conjugated with one or more saccharide moieties are expected to be useful as targeted drug-delivery systems. We prepared a cyclodextrin conjugated with two arbutin moieties, which was designed as a model for a drug carrier having a high ability for the inclusion of the anticancer agent doxorubicin. Studies using a surface plasmon resonance optical biosensor showed that the cyclodextrin derivative has an extremely high association constant of 1.4 10 8 M-1 for immobilized doxorubicin.

Cite this article as:

Yamanoi Takashi, Kobayashi Natsumi, Takahashi Keiko and Hattori Kenjiro, Preparation of a Cyclodextrin Conjugated With Two Arbutin Moieties as a Drug-Carrier Model, and its High Ability for the Inclusion of Doxorubicin, Letters in Drug Design & Discovery 2006; 3 (3) . https://dx.doi.org/10.2174/157018006776286925