Abstract
Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.
Keywords: Alzheimer's disease, amyloid β-protein, aggregation, fibril formation, quasielastic light scattering, regularization, elongation, nucleation
Protein & Peptide Letters
Title: Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation
Volume: 13 Issue: 3
Author(s): Aleksey Lomakin and David B. Teplow
Affiliation:
Keywords: Alzheimer's disease, amyloid β-protein, aggregation, fibril formation, quasielastic light scattering, regularization, elongation, nucleation
Abstract: Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.
Export Options
About this article
Cite this article as:
Lomakin Aleksey and Teplow B. David, Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation, Protein & Peptide Letters 2006; 13 (3) . https://dx.doi.org/10.2174/092986606775338515
DOI https://dx.doi.org/10.2174/092986606775338515 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Novel Target Sites for Drug Screening: A Special Reference to Cancer, Rheumatoid Arthritis and Parkinson’s Disease
Current Signal Transduction Therapy B-Cell Based Gene Therapy for Autoimmune Diseases
Infectious Disorders - Drug Targets Multivalent Cooperative Catalysts
Current Organic Chemistry Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimers Disease
Current Medicinal Chemistry Patent Selections:
Recent Patents on CNS Drug Discovery (Discontinued) Ischemic Colitis: Current Diagnosis and Treatment
Current Drug Targets Prevention of Macrovascular Disease in Type 2 Diabetic Patients: Blockade of the Renin-Angiotensin-Aldosterone System
Current Diabetes Reviews Rheological Characteristics of Novel Meloxicam-Loaded Complex Organogels Based on Fumed Silica and Poloxamer
Current Drug Delivery Editorial: Conceptualizing Adolescent Problems in Dimensional Terms
Adolescent Psychiatry Disturbed Sleep Patterns in Elders with Mild Cognitive Impairment: The Role of Memory Decline and ApoE ε 4 Genotype
Current Alzheimer Research The Role of TMP21 in Trafficking and Amyloid-β Precursor Protein (APP) Processing in Alzheimer’s Disease
Current Alzheimer Research Environmental Enrichment as a Positive Behavioral Intervention Across the Lifespan
Current Neuropharmacology Editorial [Hot Topic: Perspectives in Integrin Blocking (Executive Editor: C. Marcinkiewicz)]
Current Pharmaceutical Design Are Raw Scores on Memory Tests Better than Age- and Education- Adjusted Scores for Predicting Progression from Amnesic Mild Cognitive Impairment to Alzheimer Disease ?
Current Alzheimer Research Current Approaches for the Treatment with Thyroid Hormone Analogs
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Myocardial Insulin Resistance and Cardiac Complications of Diabetes
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The Proteasome in Health and Disease
Current Pharmaceutical Design Interferon alpha for Treatment of Chronic Myeloid Leukemia
Current Drug Targets Editorial [Hot Topic: Recent Advances and Future Prospect in Protease Targeting (Executive Editor: B. Turk) ]
Current Pharmaceutical Design The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration
Current Molecular Medicine