Drug Targets for Plasmodium falciparum: A Post-Genomic Review/Survey

Iwei      Yeh; Russ   B.   Altman

Abstract

Over 300 million cases of malaria each year cause significant morbidity and mortality. Growing drugresistance among the Plasmodia that cause malaria motivates the development of additional anti-malarial drugs. This review summarizes the current state of knowledge about potential drug targets for malaria. The recently sequenced malaria genome data clarifies parasite metabolic pathways, and more metabolic targets have been identified.

Keywords: Malaria, drug targets, plasmodium, metabolism, genomics

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Mini-Reviews in Medicinal Chemistry

Title: Drug Targets for Plasmodium falciparum: A Post-Genomic Review/Survey

Volume: 6 Issue: 2

Author(s): Iwei Yeh and Russ B. Altman

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Keywords: Malaria, drug targets, plasmodium, metabolism, genomics

Abstract: Over 300 million cases of malaria each year cause significant morbidity and mortality. Growing drugresistance among the Plasmodia that cause malaria motivates the development of additional anti-malarial drugs. This review summarizes the current state of knowledge about potential drug targets for malaria. The recently sequenced malaria genome data clarifies parasite metabolic pathways, and more metabolic targets have been identified.

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Yeh Iwei and Altman B. Russ, Drug Targets for Plasmodium falciparum: A Post-Genomic Review/Survey, Mini-Reviews in Medicinal Chemistry 2006; 6 (2) . https://dx.doi.org/10.2174/138955706775475957

DOI https://dx.doi.org/10.2174/138955706775475957	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607

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