Abstract
E5880, a novel platelet activating factor receptor antagonist, was dispersed in water for use in injectable formulation and the physicochemical properties of the preparation were characterized. The critical concentration for formation of micelles was 0.12 mM. Using area per molecule data, the critical packing parameter was calculated, indicating that the structure of the micelle was spherical and that each micelle contained 49 molecules. The diameter of the micelle was 8.1 nm. Attractive interactions occurred between E5880 molecules in the micelle. The hydrocarbon region in the micelle was more rigid and less hydrated than that of other surfactants, stearyltrimethyl-ammonium chloride and cetyltrimethylammonium chloride.
Keywords: PAF antagonist, surface tension, micelle, structure, micropolarity
Letters in Drug Design & Discovery
Title: Characterization of the Physicochemical Properties of Micelles Composed of the Novel Platelet Activating Factor Receptor Antagonist, E5880 in an Aqueous Environment
Volume: 3 Issue: 2
Author(s): Yasuyuki Asai
Affiliation:
Keywords: PAF antagonist, surface tension, micelle, structure, micropolarity
Abstract: E5880, a novel platelet activating factor receptor antagonist, was dispersed in water for use in injectable formulation and the physicochemical properties of the preparation were characterized. The critical concentration for formation of micelles was 0.12 mM. Using area per molecule data, the critical packing parameter was calculated, indicating that the structure of the micelle was spherical and that each micelle contained 49 molecules. The diameter of the micelle was 8.1 nm. Attractive interactions occurred between E5880 molecules in the micelle. The hydrocarbon region in the micelle was more rigid and less hydrated than that of other surfactants, stearyltrimethyl-ammonium chloride and cetyltrimethylammonium chloride.
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Cite this article as:
Asai Yasuyuki, Characterization of the Physicochemical Properties of Micelles Composed of the Novel Platelet Activating Factor Receptor Antagonist, E5880 in an Aqueous Environment, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789685
DOI https://dx.doi.org/10.2174/157018006775789685 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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