Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles

Title: Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles

Volume: 3 Issue: 2

Author(s): A. S. Carvalho, D. Gibaldi, A. C. Pinto, M. Bozza and N. Boechat

Affiliation:

Keywords: 1,3,4-thiadiazole derivative, nucleophilic aromatic substitution, megazol, trypanocidal activity

Abstract: A new series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles (6ah) has been designed, synthesized and examined for their ability against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution. Several bases were investigated as proton scavengers, and lithium diisopropylamide (LDA) was found to be the best base giving products in good yields.

Cite this article as:

Carvalho S. A., Gibaldi D., Pinto C. A., Bozza M. and Boechat N., Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789667