Abstract
In this prospective, randomized, double-blinded study, clonidine was found an efficient adjunct to local anesthetics for increasing the intensity of axillary brachial plexus block. Similar clonidine dose had no such effect when administered intramuscularly, suggesting a local, neural effect. Blood absorption was similar in both cases, leading to central action as sedation.
Keywords: Adrenergic agonists, adrenergic a-agonists, anesthesia, conduction, nerve block, pharmacology, plasma clonidine concentration
Letters in Drug Design & Discovery
Title: Improved Sensory Blockade by Clonidine Added to Axillary Block Solution. Resulting Plasma Clonidine Concentration
Volume: 3 Issue: 2
Author(s): Jean-Marc Bernard
Affiliation:
Keywords: Adrenergic agonists, adrenergic a-agonists, anesthesia, conduction, nerve block, pharmacology, plasma clonidine concentration
Abstract: In this prospective, randomized, double-blinded study, clonidine was found an efficient adjunct to local anesthetics for increasing the intensity of axillary brachial plexus block. Similar clonidine dose had no such effect when administered intramuscularly, suggesting a local, neural effect. Blood absorption was similar in both cases, leading to central action as sedation.
Export Options
About this article
Cite this article as:
Bernard Jean-Marc, Improved Sensory Blockade by Clonidine Added to Axillary Block Solution. Resulting Plasma Clonidine Concentration, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789739
DOI https://dx.doi.org/10.2174/157018006775789739 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Ignored Role of Intraoperative Hypotension in Producing Postoperative Acute Kidney Injury-An Obligatory Appeal for More Preventative Nephrology
Current Hypertension Reviews Therapy in Prion Diseases
Current Topics in Medicinal Chemistry Management and Treatment of Cardiovascular Diseases in the Elderly
Current Pharmacogenomics and Personalized Medicine Antiarrhythmic Therapy on Prevention of Postoperative Atrial Fibrillation in Patients After Heart Surgery
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Melphalan in Regional Chemotherapy for Locally Recurrent Metastatic Melanoma
Current Topics in Medicinal Chemistry A Review on Phytochemistry and Pharmacology of Medicinal as well as Poisonous Mushrooms
Mini-Reviews in Medicinal Chemistry Strategies to Reduce Oxidative Stress in Glaucoma Patients
Current Neuropharmacology Diabetes and Nutritional Screening in Post-Bariatric Patients
Current Diabetes Reviews Cardiovascular Effects of Phosphodiesterase 5 Inhibitors
Current Pharmaceutical Design A Comparative Effectiveness Systematic Review and Meta-analysis of Drugs for the Prophylaxis of Junctional Ectopic Tachycardia
Current Cardiology Reviews Attacking HIV Provirus: Therapeutic Strategies to Disrupt Persistent Infection
Infectious Disorders - Drug Targets Pulmonary Hypertension: Types and Treatments
Current Cardiology Reviews Anti-Cancer, Pharmacokinetic and Biodistribution Studies of Cremophor EL Free Alternative Paclitaxel Formulation
Current Drug Safety Treating Cancer and No-Cancer Pain in Older and Oldest Old Patients
Current Pharmaceutical Design Blood Pressure Variability/Dipper/Non-dipper in Hypertension and Diabetes
Current Hypertension Reviews Docking, Synthesis and Anti-Diabetic Activity of Novel Sulfonylhydrazone Derivatives Designed as PPAR-Gamma Agonists
Current Topics in Medicinal Chemistry Treatment of Chronic Pain with Drugs that Modulate Central Nervous System Serotonin and Norepinephrine
Current Drug Therapy Hypersensitivity Reactions to Neuromuscular Blocking Agents
Current Pharmaceutical Design Cellular Mechanisms of Brain Injury and Cell Death
Current Pharmaceutical Design Pharmacophore Development and SAR Studies of Imidazoline Receptor Ligands
Mini-Reviews in Medicinal Chemistry