Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Title: Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Volume: 3 Issue: 2

Author(s): Hua Lu, Haixia Lin, Yi Jiang, Xinguang Zhou, Beili Wu and Jianmin Chen

Affiliation:

Keywords: Camptothecin, ester, succinate, prodrug, antitumor

Abstract: A series of new 20-O-linked succinate-based camptothecin ester derivatives were synthesized and their cytotoxicities were tested on five human cancer cell lines by MTT assay. All the derivatives showed moderate antitumor activity in vitro, and they were 20-to-several thousand-fold less toxic than their parent drug.

Cite this article as:

Lu Hua, Lin Haixia, Jiang Yi, Zhou Xinguang, Wu Beili and Chen Jianmin, Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789757