Abstract
A novel chemically-modified insulin, ε-NB29-lipoyl insulin, was selectively prepared by the covalent linkage of α-lipoic acid (LA) to the ε-amino group of LysB29 of insulin without any protecting agent and analyzed by PAGE, HPLC, MALDI-TOF-MS. Monolipoyl- insulin maintained the glucose-lowering effect as well as native insulin and showed A longer duration of action than native insulin and an inhibitory effect towards trypsin degradation.
Keywords: Insulin, α-lipoic acid, chemical modification, lipoyl-insulin, monolipoyl-insulin
Protein & Peptide Letters
Title: Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid
Volume: 13 Issue: 2
Author(s): Tao Huang and Kaixun Huang
Affiliation:
Keywords: Insulin, α-lipoic acid, chemical modification, lipoyl-insulin, monolipoyl-insulin
Abstract: A novel chemically-modified insulin, ε-NB29-lipoyl insulin, was selectively prepared by the covalent linkage of α-lipoic acid (LA) to the ε-amino group of LysB29 of insulin without any protecting agent and analyzed by PAGE, HPLC, MALDI-TOF-MS. Monolipoyl- insulin maintained the glucose-lowering effect as well as native insulin and showed A longer duration of action than native insulin and an inhibitory effect towards trypsin degradation.
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Cite this article as:
Huang Tao and Huang Kaixun, Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid, Protein & Peptide Letters 2006; 13 (2) . https://dx.doi.org/10.2174/092986606775101599
DOI https://dx.doi.org/10.2174/092986606775101599 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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