Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Benzodiazepine Based Privileged Structures

Ahmed      Kamal; K.   L.   Reddy; V.      Devaiah; N.      Shankaraiah; D.   R.   Reddy

Abstract

Benzodiazepine based heterocycles can be prepared efficiently on solid-support by employing different approaches. In this review, an effort has been made to highlight academic and industrial examples of combinatorial synthesis for this type of heterocycles published in the last decade. Therefore, it describes synthetic strategies for the generation of benzodiazepine privileged structures employing the corresponding resin-bound substrates. Further, the most relevant biological properties of these heterocycles have also been incorporated.

Keywords: heterocycles, cyclocondensation, combinatorial library, peptidomimetics, 4,5-dihydro-1H-1,4-benzodiazepine-2,3-diones, one-pot elimination-cyclization

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Mini-Reviews in Medicinal Chemistry

Title: Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Benzodiazepine Based Privileged Structures

Volume: 6 Issue: 1

Author(s): Ahmed Kamal, K. L. Reddy, V. Devaiah, N. Shankaraiah and D. R. Reddy

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Keywords: heterocycles, cyclocondensation, combinatorial library, peptidomimetics, 4,5-dihydro-1H-1,4-benzodiazepine-2,3-diones, one-pot elimination-cyclization

Abstract: Benzodiazepine based heterocycles can be prepared efficiently on solid-support by employing different approaches. In this review, an effort has been made to highlight academic and industrial examples of combinatorial synthesis for this type of heterocycles published in the last decade. Therefore, it describes synthetic strategies for the generation of benzodiazepine privileged structures employing the corresponding resin-bound substrates. Further, the most relevant biological properties of these heterocycles have also been incorporated.

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Kamal Ahmed, Reddy L. K., Devaiah V., Shankaraiah N. and Reddy R. D., Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Benzodiazepine Based Privileged Structures, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197875

DOI https://dx.doi.org/10.2174/138955706775197875	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607

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