Abstract
Solid-phase chemistry, first introduced for peptide synthesis in the 1960s, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
Keywords: Pictet-Spengler reaction, dehydrative cyclization, antitumor, prostaglandin, Combinatorial libraries, galanthamine-like compounds, carpanone
Mini-Reviews in Medicinal Chemistry
Title: Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products
Volume: 6 Issue: 1
Author(s): Alvarez Cironi, Mercedes Alvarez and Fernando Albericio
Affiliation:
Keywords: Pictet-Spengler reaction, dehydrative cyclization, antitumor, prostaglandin, Combinatorial libraries, galanthamine-like compounds, carpanone
Abstract: Solid-phase chemistry, first introduced for peptide synthesis in the 1960s, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
Export Options
About this article
Cite this article as:
Cironi Alvarez, Alvarez Mercedes and Albericio Fernando, Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197857
DOI https://dx.doi.org/10.2174/138955706775197857 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Patents on Biomarkers in Oral Cancers
Recent Patents on Biomarkers The Meaning of Different Forms of Structural Myocardial Injury, Immune Response and Timing of Infarct Necrosis and Cardiac Repair
Current Vascular Pharmacology Adult Neurogenesis in the Olfactory System and Neurodegenerative Disease
Current Molecular Medicine Schistosoma mansoni Antigens as Modulators of the Allergic Inflammatory Response in Asthma
Endocrine, Metabolic & Immune Disorders - Drug Targets Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis
Current Drug Metabolism Aptamer-based Emerging Tools for Viral Biomarker Detection: A Focus on SARS-CoV-2
Current Medicinal Chemistry Targeted Therapies – Many Ways to (the Peace of) Rome
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) A State-of-the-Art Review on Opioids Induced Constipation and its Management
Current Indian Science Hepatic Angiogenesis and Fibrogenesis in the Progression of Chronic Liver Diseases
Current Angiogenesis (Discontinued) Potential Molecular Targeted Therapeutics: Role of PI3-K/Akt/mTOR Inhibition in Cancer
Anti-Cancer Agents in Medicinal Chemistry Histone Deacetylases as Targets for Dietary Cancer Preventive Agents: Lessons Learned with Butyrate, Diallyl Disulfide, and Sulforaphane
Current Drug Targets The Cytokine Network in HIV Infection
Current Molecular Medicine Virtual Screening Strategies in Drug Discovery: A Critical Review
Current Medicinal Chemistry Modulation of Platelet Function and Signaling by Flavonoids
Mini-Reviews in Medicinal Chemistry Bronchoalveolar Lavage in Hypersensitivity Pneumonitis: A Series of 139 Patients
Inflammation & Allergy - Drug Targets (Discontinued) Suicidal emperipolesis: a process leading to cell-in-cell structures, T cell clearance and immune homeostasis.
Current Molecular Medicine Molecule of the Month
Current Topics in Medicinal Chemistry Nanoceria: Synthesis and Biomedical Applications
Current Nanoscience The Gut Mucosa as a Site for Induction of Regulatory T-Cells
Current Pharmaceutical Design Natural Products with Health Benefits from Marine Biological Resources
Current Organic Chemistry