Solid-Phase Synthesis in the Twenty-First Century

Title: Solid-Phase Synthesis in the Twenty-First Century

Volume: 6 Issue: 1

Author(s): A. Ganesan

Affiliation:

Keywords: Solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, Pictet-Spengler reaction, depsipeptides

Abstract: Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-β-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the antimycobacterial cyclic depsipeptide natural product kahalalide A.

Cite this article as:

Ganesan A., Solid-Phase Synthesis in the Twenty-First Century, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197866