Abstract
Biocompatible nano-composite sol (NCS) comprising nano-crystalline hydroxyapatite (HAp, Ca 10(PO4)6(OH)2) and hyaluronic acid (HYA) was prepared. By varying the relative content of HAp in NCS, strongest network structure was obtained at 10wt% HAp in NCS, as confirmed from a number of circumstance evidences obtained by rheological, thermoanalytical, crystallographical measurements as well as FT-IR spectra. Interaction of NCS with natural bones and gut strings made from gut collagen was then examined in vitro. Adhesion of the collagen fibers with NCS was observed at the fracture surface of natural bones. Gut collagen was disentangled to the fragments of about 10 nm thick, where no NCS was observed, thus, confirming the fact that the adhesive strength between NCS and bone surface is stronger than that among collagen fibers.
Keywords: Biocompatible nano-composite sol, Hydroxyapatite, Hyaluronic acid, Collagen fibers, Adhesive strength
Current Nanoscience
Title: Properties of Hydroxyapatite - Hyaluronic Acid Nano-Composite Sol and its Interaction with Natural Bones and Collagen Fibers
Volume: 2 Issue: 3
Author(s): Y. Ishikawa, J. Komotori and M. Senna
Affiliation:
Keywords: Biocompatible nano-composite sol, Hydroxyapatite, Hyaluronic acid, Collagen fibers, Adhesive strength
Abstract: Biocompatible nano-composite sol (NCS) comprising nano-crystalline hydroxyapatite (HAp, Ca 10(PO4)6(OH)2) and hyaluronic acid (HYA) was prepared. By varying the relative content of HAp in NCS, strongest network structure was obtained at 10wt% HAp in NCS, as confirmed from a number of circumstance evidences obtained by rheological, thermoanalytical, crystallographical measurements as well as FT-IR spectra. Interaction of NCS with natural bones and gut strings made from gut collagen was then examined in vitro. Adhesion of the collagen fibers with NCS was observed at the fracture surface of natural bones. Gut collagen was disentangled to the fragments of about 10 nm thick, where no NCS was observed, thus, confirming the fact that the adhesive strength between NCS and bone surface is stronger than that among collagen fibers.
Export Options
About this article
Cite this article as:
Ishikawa Y., Komotori J. and Senna M., Properties of Hydroxyapatite - Hyaluronic Acid Nano-Composite Sol and its Interaction with Natural Bones and Collagen Fibers, Current Nanoscience 2006; 2 (3) . https://dx.doi.org/10.2174/1573413710602030191
DOI https://dx.doi.org/10.2174/1573413710602030191 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
DNA Microarrays - An Armory for Combating Infectious Diseases in the New Century
Infectious Disorders - Drug Targets Effects of Biphenyl Sulfonylamino Methyl Bisphosphonic Acids on Porphyromonas Gingivalis and Cytokine Secretion by Oral Epithelial Cells
Medicinal Chemistry Patients with Hereditary Hemorrhagic Telangectasia (HHT) Exhibit a Deficit of Polymorphonuclear Cell and Monocyte Oxidative Burst and Phagocytosis: A Possible Correlation with Altered Adaptive Immune Responsiveness in HHT
Current Pharmaceutical Design Bacterial β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) as a Target for Novel Antibacterial Agents Design
Current Medicinal Chemistry Osteonecrosis of the Jaw and Angiogenesis inhibitors: A Revival of a Rare but Serous Side Effect
Current Medicinal Chemistry Novel Anticancer Targets and Drug Discovery in Post Genomic Age
Current Medicinal Chemistry - Anti-Cancer Agents Identifying Biomarkers of Lung Cancer in the Post-Genomic Era
Current Pharmacogenomics Local Delivery of Minocycline Hydrochloride: A Therapeutic Paradigm in Periodontal Diseases
Current Drug Delivery Biochemical Strategies to Anticoagulation: A Comparative Overview
Current Vascular Pharmacology The Top 102 Most Cited Publications Relevant to Dental Education
Current Dentistry Antioxidant Effects of Glutathione and IGF in a Hyperglycaemic Cell Culture Model of Fibroblasts: Some Actions of Advanced Glycaemic end Products (AGE) and Nicotine
Endocrine, Metabolic & Immune Disorders - Drug Targets Polymer Particulates in Drug Delivery
Current Pharmaceutical Design Challenges of Stem-cell-based Craniofacial Regeneration
Current Stem Cell Research & Therapy Building of Bio-complexes in Maxillofacial Tissue Engineering
Current Tissue Engineering (Discontinued) Use of BNP and CRP as Biomarkers in Assessing Cardiovascular Disease:Diagnosis Versus Risk
Current Vascular Pharmacology Doxycycline Inhibition of Abdominal Aortic Aneurysm Growth - A Systematic Review of the Literature
Current Vascular Pharmacology Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF): Surgical Adjuvants, Preparations for In Situ Regenerative Medicine and Tools for Tissue Engineering
Current Pharmaceutical Biotechnology Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases
Current Pharmacogenomics Immune-Mediated Mechanisms in Atherosclerosis: Prevention and Treatment of Clinical Manifestations
Current Pharmaceutical Design Emerging Molecular Targets for Treatment of Erectile Dysfunction: Vascular and Regenerative Therapies on the Horizon
Current Drug Targets