Abstract
During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of Lacetylcarnitine as tested in clinical studies and in animal models of nerve injury.
Keywords: L-acetylcarnitine, neuropathic pain, peripheral neuropathies, antinociception
Current Neuropharmacology
Title: L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies
Volume: 4 Issue: 3
Author(s): S. Chiechio, A. Copani, F. Nicoletti and R. W. Gereau IV
Affiliation:
Keywords: L-acetylcarnitine, neuropathic pain, peripheral neuropathies, antinociception
Abstract: During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of Lacetylcarnitine as tested in clinical studies and in animal models of nerve injury.
Export Options
About this article
Cite this article as:
Chiechio S., Copani A., Nicoletti F. and Gereau IV W. R., L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies, Current Neuropharmacology 2006; 4 (3) . https://dx.doi.org/10.2174/157015906778019509
DOI https://dx.doi.org/10.2174/157015906778019509 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Systems Biology of Apoptosis and Survival: Implications for Drug Development
Current Pharmaceutical Design Resveratrol: A Multifunctional Cytoprotective Molecule
Current Pharmaceutical Biotechnology Therapeutic Potential of Hepatocyte Growth Factor for Treating Neurological Diseases
Current Drug Therapy The Impact of IL-17 in Atherosclerosis
Current Medicinal Chemistry Calcium Ion – The Key Player in Cerebral Ischemia
Current Medicinal Chemistry Is There a Role for Cytokine Based Therapies in Fibromyalgia
Current Pharmaceutical Design Therapeutic Potential of Targeting TREM-1 in Inflammatory Diseases and Cancer
Current Pharmaceutical Design Anti-Inflammatory Drugs in the Treatment of Neurodegenerative Diseases: Current State
Current Pharmaceutical Design Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences
Current Drug Targets Patents on Non-Viral Mediated Gene Delivery
Recent Patents on DNA & Gene Sequences Oxidative Stress Modulation Through Habitual Physical Activity
Current Pharmaceutical Design Targeting the Metabotropic Glutamate Receptor mGluR4 for the Treatment of Diseases of the Central Nervous System
Current Topics in Medicinal Chemistry Anti-inflammatory strategies in stroke: a potential therapeutic target
Current Vascular Pharmacology Poly(ADP-Ribose) Polymerase Inhibitors: New Pharmacological Functions and Potential Clinical Implications
Current Pharmaceutical Design Patent Selections
Recent Patents on Biotechnology Rosuvastatin may have Neuroprotective Effect on Spinal Cord Ischemia Reperfusion Injury
CNS & Neurological Disorders - Drug Targets Current Concepts in Reprogramming Somatic Cells to Pluripotent State
Current Stem Cell Research & Therapy Adult Stem Cell Treatment for Central Nervous System Injury
Current Tissue Engineering (Discontinued) Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection
Current Pharmaceutical Design From Cerebrospinal Fluid Pulsation to Noninvasive Intracranial Compliance and Pressure Measured by MRI Flow Studies
Current Medical Imaging