Abstract
Interleukin-26 (IL-26) belongs to the family of cellular cytokines which share sequence homology with IL-10, however, without functional conservation. The il-26 gene is situated on the human chromosome 12q15 in close neighbourhood to the genes for the related T-cellular cytokines interferon-γ (IFN-γ) and IL-22. il-26 was discovered due to its overexpression in T cells after growth transformation with herpesvirus saimiri. IL-26 is produced by activated T cells, forms homodimers, and acts on epithelial target cells such as colon carcinoma cells or keratinocytes. Presumably due to its positive net charge, IL-26 adheres to glycosaminoglycans on cell surfaces. Stimulation with IL-26 results in the phosphorylation and activation of the transcription factors STAT1 and STAT3 and in the induction of CD54 surface expression and secretion of cytokines such as IL-8 and IL-10. These effects are mediated by an IL-26-specific receptor complex consisting of IL-20R1 and IL-10R2. Thus, IL-26 appears to be a rather proinflammatory and cell-surface associated cytokine linking local T-cell activation with epithelial functions.
Keywords: AK155, colon carcinoma, ICAM-1, Interleukin-26, IL-26, herpesvirus saimiri, STAT, T cell
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Interleukin-26, An Epitheliotropic T-Cell Cytokine
Volume: 5 Issue: 3
Author(s): Oliver Braum, Heide Pirzer and Helmut Fickenscher
Affiliation:
Keywords: AK155, colon carcinoma, ICAM-1, Interleukin-26, IL-26, herpesvirus saimiri, STAT, T cell
Abstract: Interleukin-26 (IL-26) belongs to the family of cellular cytokines which share sequence homology with IL-10, however, without functional conservation. The il-26 gene is situated on the human chromosome 12q15 in close neighbourhood to the genes for the related T-cellular cytokines interferon-γ (IFN-γ) and IL-22. il-26 was discovered due to its overexpression in T cells after growth transformation with herpesvirus saimiri. IL-26 is produced by activated T cells, forms homodimers, and acts on epithelial target cells such as colon carcinoma cells or keratinocytes. Presumably due to its positive net charge, IL-26 adheres to glycosaminoglycans on cell surfaces. Stimulation with IL-26 results in the phosphorylation and activation of the transcription factors STAT1 and STAT3 and in the induction of CD54 surface expression and secretion of cytokines such as IL-8 and IL-10. These effects are mediated by an IL-26-specific receptor complex consisting of IL-20R1 and IL-10R2. Thus, IL-26 appears to be a rather proinflammatory and cell-surface associated cytokine linking local T-cell activation with epithelial functions.
Export Options
About this article
Cite this article as:
Braum Oliver, Pirzer Heide and Fickenscher Helmut, Interleukin-26, An Epitheliotropic T-Cell Cytokine, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2006; 5 (3) . https://dx.doi.org/10.2174/187152306778017674
DOI https://dx.doi.org/10.2174/187152306778017674 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Link between Intravascular Hemolysis and Vascular Occlusion in Sickle Cell Disease
Current Vascular Pharmacology Ocular Implants – A Novel Approach in Ocular Drug Delivery
Recent Patents on Nanomedicine Therapeutic Intervention in Cancer and Chronic Viral Infections: Antibody Mediated Manipulation of PD-1/PD-L1 Interaction
Reviews on Recent Clinical Trials Th17-Related Cytokines in Inflammatory Bowel Diseases: Friends or Foes?
Current Molecular Medicine Emerging Therapeutic Strategies for Hepatitis C Virus Infection
Current Molecular Pharmacology Editorial (Thematic Issue: Macrophage Migration Inhibitory Factor (MIF) and Its Receptors – Interactions and Suitability as Biomarkers)
Mini-Reviews in Medicinal Chemistry Heat Shock Proteins: Mediators of Atherosclerotic Development
Current Drug Targets Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
Current Pharmaceutical Design Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis
Current Pharmaceutical Design Synthetic Peptides in the Diagnosis of Systemic Autoimmune Diseases
Current Protein & Peptide Science Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Perinatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview
Current Pharmaceutical Design BHUx: A Patented Polyherbal Formulation to Prevent Hyperlipidemia and Atherosclerosis
Recent Patents on Inflammation & Allergy Drug Discovery Olive Oil and Haemostasis
Current Nutrition & Food Science CD164 as a Basophil Activation Marker
Current Pharmaceutical Design Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities
Mini-Reviews in Organic Chemistry Life or Death of T Cells with Antigen-Specific Receptors - Using T Cells for Cancer Adoptive Immunotherapy / Gene Therapy
Current Gene Therapy Meet Our Editorial Board Member
Current Rheumatology Reviews Meet the Editor
Reviews on Recent Clinical Trials An Update on Management of Acute and Chronic Open Wounds: The Importance of Moist Environment in Optimal Wound Healing
Medicinal Chemistry Reviews - Online (Discontinued) Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine
CNS & Neurological Disorders - Drug Targets