Abstract
This review summarizes recent data on the use of HSV-1 – based amplicon vectors for in vivo gene delivery to the brains of rats and mice to study and modify behaviour. Here we describe studies that have focused on cognitive functions like learning and memory. In addition, the use of amplicons in other behavioural studies, like addiction, social interaction, anxiety and stress, will be briefly updated. Several remarkable findings have been achieved, thanks to the use of these very efficient and non-toxic naturally neurotropic vectors, most particularly the consistent observation that genetic manipulation of a rather limited number of neurons in restricted regions of the brain, could result in significant behavioural changes, a notion that is therefore emerging as a common unifying hypothesis, thanks to these works.
Keywords: HSV-1 vectors, Addiction, ventral tegmental area (VTA), cAMP response element-binding protein (CREB), NMDAR-mediated synaptic plasticity, memory
Current Gene Therapy
Title: Amplicon Vectors as Outstanding Tools to Study and Modify Cognitive Functions
Volume: 6 Issue: 3
Author(s): Diana Jerusalinsky and Alberto L. Epstein
Affiliation:
Keywords: HSV-1 vectors, Addiction, ventral tegmental area (VTA), cAMP response element-binding protein (CREB), NMDAR-mediated synaptic plasticity, memory
Abstract: This review summarizes recent data on the use of HSV-1 – based amplicon vectors for in vivo gene delivery to the brains of rats and mice to study and modify behaviour. Here we describe studies that have focused on cognitive functions like learning and memory. In addition, the use of amplicons in other behavioural studies, like addiction, social interaction, anxiety and stress, will be briefly updated. Several remarkable findings have been achieved, thanks to the use of these very efficient and non-toxic naturally neurotropic vectors, most particularly the consistent observation that genetic manipulation of a rather limited number of neurons in restricted regions of the brain, could result in significant behavioural changes, a notion that is therefore emerging as a common unifying hypothesis, thanks to these works.
Export Options
About this article
Cite this article as:
Jerusalinsky Diana and Epstein L. Alberto, Amplicon Vectors as Outstanding Tools to Study and Modify Cognitive Functions, Current Gene Therapy 2006; 6 (3) . https://dx.doi.org/10.2174/156652306777592027
DOI https://dx.doi.org/10.2174/156652306777592027 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Genome-Scale Technologies Foster Advances in Neurological and Behavioral Research
Current Psychiatry Reviews Predicting Progression from Cognitive Impairment to Alzheimer’s Disease with the Disease State Index
Current Alzheimer Research Effects of the KIBRA Single Nucleotide Polymorphism on Synaptic Plasticity and Memory: A Review of the Literature
Current Neuropharmacology Targeting of Peripherally Expressed Pain-Related Molecules in Injury- Induced Chronic Neuropathic Pain
CNS & Neurological Disorders - Drug Targets Nicotinic Receptors Containing the α7 Subunit: A Model for Rational Drug Design
Current Medicinal Chemistry Macrolides Allergy
Current Pharmaceutical Design Role of Physical Exercise as Complementary Treatment for Epilepsy and other Brain Disorders
Current Pharmaceutical Design Involvement of Cytosolic Phospholipase A2, Calcium Independent Phospholipase A2 and Plasmalogen Selective Phospholipase A2 in Neurodegenerative and Neuropsychiatric Conditions
Current Medicinal Chemistry HTR2A Gene Variants and Psychiatric Disorders: A Review of Current Literature and Selection of SNPs for Future Studies
Current Medicinal Chemistry Sweet and Sour - Oxidative and Carbonyl Stress in Neurological Disorders
CNS & Neurological Disorders - Drug Targets Psychological Treatments for Hypochondriasis: A Narrative Review
Current Psychiatry Reviews Silencing the Brain May be Better than Stimulating it. The GABA Effect
Current Pharmaceutical Design The Perfect Storm: The High Prevalence Low Severity Outcomes of the Preterm Survivors
Current Pediatric Reviews Microfluidic Devices for Automation of Assays on Drosophila Melanogaster for Applications in Drug Discovery and Biological Studies
Current Pharmaceutical Biotechnology A Glycemic Threshold of 90 mg/dl Promotes Early Signs of Atherosclerosis in Apparetly Healthy Overweight/Obese Subjects
Endocrine, Metabolic & Immune Disorders - Drug Targets Overview of Pediatric Epilepsy
Current Pediatric Reviews Histamine H<sub>4</sub> Receptor Antagonists: A New Approach for Tinnitus Treatment?
Recent Patents on CNS Drug Discovery (Discontinued) N-Acetylcysteine for the Treatment of Obsessive-Compulsive Disorder
Current Psychiatry Reviews Undesired Neural Side-Effects of a Drug, a Chemical and Genetic Interrelated Problem
Central Nervous System Agents in Medicinal Chemistry Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine
Current Pharmaceutical Biotechnology