Abstract
How organismal complexity is achieved is a fundamental biological issue. The surprising revelation that complex eukaryotes have fewer than expected genes presents an important challenge for deciphering how organisms achieve complexity. The genome size and the gene number do not necessarily correlate in a consistent manner with the perceived organismal complexity. In this review, we focus on known molecular mechanisms that increase genetic complexity at the molecular and functional levels, and discuss features that have likely contributed to organismal complexity.
Keywords: TATA-binding protein (TBP), bacterial operons, ubiquitin, transcriptome, Somatic recombination, Polyadenylation
Current Genomics
Title: Building Biological Complexity with Limited Genes
Volume: 7 Issue: 2
Author(s): Ravinder Singh, Mark D. Robida and Sina Karimpour
Affiliation:
Keywords: TATA-binding protein (TBP), bacterial operons, ubiquitin, transcriptome, Somatic recombination, Polyadenylation
Abstract: How organismal complexity is achieved is a fundamental biological issue. The surprising revelation that complex eukaryotes have fewer than expected genes presents an important challenge for deciphering how organisms achieve complexity. The genome size and the gene number do not necessarily correlate in a consistent manner with the perceived organismal complexity. In this review, we focus on known molecular mechanisms that increase genetic complexity at the molecular and functional levels, and discuss features that have likely contributed to organismal complexity.
Export Options
About this article
Cite this article as:
Singh Ravinder, Robida D. Mark and Karimpour Sina, Building Biological Complexity with Limited Genes, Current Genomics 2006; 7 (2) . https://dx.doi.org/10.2174/138920206777304669
DOI https://dx.doi.org/10.2174/138920206777304669 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synthesis and Applications of Glyconanoparticles
Current Organic Chemistry Melanoma Immunotherapy: Past, Present, and Future
Current Pharmaceutical Design Natural Killer T Cells as Targets for Therapeutic Intervention in Autoimmune Diseases
Current Pharmaceutical Design Colorectal Carcinogensis and Suppression of Tumor Development by Inhibition of Enzymes and Molecular Targets
Current Enzyme Inhibition Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications
Current Medicinal Chemistry Targeted Drug Delivery Systems for Lung Macrophages
Current Drug Targets Advanced Drug Delivery of N-Acetylcarnosine (N-Acetyl-beta-alanyl-Lhistidine), Carcinine (Beta-alanylhistamine) and L-carnosine (Beta-alanyl- L-histidine) in Targeting Peptide Compounds as Pharmacological Chaperones for Use in Tissue Engineering, Human Disease Management and Therapy: From in vitro to the Clinic
Recent Patents on Drug Delivery & Formulation Evidence for a Putative Relationship Between Type 2 Diabetes and Neoplasia with Particular Reference to Breast Cancer: Role of Hormones, Growth Factors and Specific Receptors
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Prevention of Non-immune Mediated Transfusion-related Acute Lung Injury; from Blood Bank to Patient
Current Pharmaceutical Design Monotherapy for the Treatment of Lymphedema in Children: A Review
Current Pediatric Reviews Neurological Involvement in Rheumatoid Arthritis
Current Immunology Reviews (Discontinued) Structure-Function Relationships and Clinical Applications of L-Asparaginases
Current Medicinal Chemistry Cutting through the Complexities of mTOR for the Treatment of Stroke
Current Neurovascular Research The φC31 Integrase System for Gene Therapy
Current Gene Therapy Chemoprevention of Lung Pathologies by Dietary n-3 Polyunsaturated Fatty Acids
Current Medicinal Chemistry An Apple Plus a Brazil Nut a Day Keeps the Doctors Away: Antioxidant Capacity of Foods and their Health Benefits
Current Pharmaceutical Design History and Evolution of Reproductive and Developmental Toxicology Guidelines
Current Pharmaceutical Design Application of Sugar-Base Anhydro Bridge for Modification of Nucleosides in the 2’- and/or 3’-Positions - Revisited
Current Organic Chemistry An Uncommon Case of Symptomatic Multiple Meningiomas with Bilateral Compressive Optic Neuropathy Rapidly Induced under Cyprotero ne Acetate Treatment
Current Drug Safety The Tumor Suppressor, p53 Regulates the γA-Crystallin Gene During Mouse Lens Development
Current Molecular Medicine