Growth Hormone-Releasing Factor: Structural Modification or Protection for More Potent Analogs

Title: Growth Hormone-Releasing Factor: Structural Modification or Protection for More Potent Analogs

Volume: 9 Issue: 3

Author(s): Pascal Dubreuil and Cyril Desevaux

Affiliation:

Keywords: Growth hormone-releasing factor, analogs

Abstract: Growth hormone-releasing factor was discovered in 1982 by Guillemin and has been subjected to intense investigations because of its huge potential applications. The major concerns encountered with the native molecules were their short half-lives in vivo in many species including man, precluding the practical use of these peptides for medical or production purposes. Many efforts to produce analogs of shorter length, more resistant to degradation and having higher affinity to the receptors have been made during the last decades. The present paper presents a quick review of the work done to produce such analogs.

Cite this article as:

Dubreuil Pascal and Desevaux Cyril, Growth Hormone-Releasing Factor: Structural Modification or Protection for More Potent Analogs, Combinatorial Chemistry & High Throughput Screening 2006; 9 (3) . https://dx.doi.org/10.2174/138620706776055511