Abstract
Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.
Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks
Anti-Cancer Agents in Medicinal Chemistry
Title: A Computational View of COX-2 Inhibition
Volume: 6 Issue: 3
Author(s): Philippe Chavatte and Amaury Farce
Affiliation:
Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks
Abstract: Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.
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Cite this article as:
Chavatte Philippe and Farce Amaury, A Computational View of COX-2 Inhibition, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/187152006776930909
DOI https://dx.doi.org/10.2174/187152006776930909 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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Anti-Cancer Agents in Medicinal Chemistry