The Use of Nimesulide and Its Analogues in Cancer Chemoprevention

Title: The Use of Nimesulide and Its Analogues in Cancer Chemoprevention

Volume: 6 Issue: 3

Author(s): Jean-Francois Renard, Fabien Julemont, Xavier d. Leval and Bernard Pirotte

Affiliation:

Keywords: Nimesulide, NS-398, cancer chemoprevention, NSAIDs, cyclooxygenase inhibitors, anti-proliferative, proapoptotic, N-arylmethanesulfonamides

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to be cyclooxygenase (COX) inhibitors, have been reported to exert anti-proliferative and pro-apoptotic effects on a variety of cancer cells. Since the COX-2 isoform was found to be overexpressed in a many human cancers, a particular attention was paid on the possible use of selective COX-2 inhibitors in cancer chemoprevention. The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398.

Cite this article as:

Renard Jean-Francois, Julemont Fabien, Leval d. Xavier and Pirotte Bernard, The Use of Nimesulide and Its Analogues in Cancer Chemoprevention, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/187152006776930855