Abstract
The present review focuses on a unique biomolecular construction kit including surface-layer (S-layer) proteins as basic building blocks and patterning elements, but also major classes of biological molecules such as (membrane) proteins, lipids, and heteropolysaccharides for the design of functional S-layer supported lipid membranes. The biomimetic approach copying the supramolecular building principle of most archaeal cell envelopes composed of a plasma membrane and a closely associated S-layer lattice has resulted in robust lipid membranes. Reconstitution of responsive transmembrane proteins has been demonstrated in lipid membranes generated on S-layer-coated substrates and electrodes. This is a particular challenge as one-third of all proteins are membrane proteins such as pore-forming proteins, ion channels or receptors. Hence membrane proteins are a preferred target for pharmaceuticals (currently more than 60% of all consumed drugs). This novel type of supported lipid membrane is seen as one of the most innovative strategies in membrane protein-based nanobiotechnology with potential applications that range from pharmaceutical (high-throughput) drug screening over lipid (bio)chips to the detection of biological warfare agents.
Keywords: Crystalline surface layer proteins, biomimetics, biosensor, bottom-up strategy, nanobiotechnology, supported lipid membranes
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Books
Nanoscale Field Effect Transistors: Emerging Applications
Nanoelectronics Devices: Design, Materials, and Applications Part II
Nanoelectronics Devices: Design, Materials, and Applications (Part I)
Role of Nanotechnology in Cancer Therapy
Synthesis and Applications of Semiconductor Nanostructures
Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts
Applications of Nanomaterials in Medical Procedures and Treatments
Synthesis of Nanomaterials
Nanobiotechnology: Principles and Applications
Bio-Inspired Nanotechnology
2