Abstract
Since the discovery of artificially produced radioisotopes in the 1930s, an estimated 10-12 million nuclear medicine diagnostic and therapeutic procedures are currently performed each year only in the United States. Gamma emission imaging has been successfully applied to almost every organ of the body (brain, bone, heart, kidney, lung, neuroreceptors) as well as sites of inflammation, atherosclerosis, and thrombosis. FDG-PET has been used in some of the inflammatory diseases as well. On the other hand, both alpha and beta-emitting isotopes have been evaluated for brachytherapy of rheumatoid diseases, each with different radiobiological effectiveness. The current status of radionuclides for imaging, therapy and research studies of inflammatory processes is reviewed here and a look into the future directions is described at the conclusion.
Keywords: Inflammation, radiopharmaceuticals, diagnosis, therapy, SPECT, PET, NSAID, FUO
Current Medicinal Chemistry
Title: Application of Radioisotopes in Inflammation
Volume: 13 Issue: 8
Author(s): A. R. Jalilian, M. Bineshmarvasti and S. Sardari
Affiliation:
Keywords: Inflammation, radiopharmaceuticals, diagnosis, therapy, SPECT, PET, NSAID, FUO
Abstract: Since the discovery of artificially produced radioisotopes in the 1930s, an estimated 10-12 million nuclear medicine diagnostic and therapeutic procedures are currently performed each year only in the United States. Gamma emission imaging has been successfully applied to almost every organ of the body (brain, bone, heart, kidney, lung, neuroreceptors) as well as sites of inflammation, atherosclerosis, and thrombosis. FDG-PET has been used in some of the inflammatory diseases as well. On the other hand, both alpha and beta-emitting isotopes have been evaluated for brachytherapy of rheumatoid diseases, each with different radiobiological effectiveness. The current status of radionuclides for imaging, therapy and research studies of inflammatory processes is reviewed here and a look into the future directions is described at the conclusion.
Export Options
About this article
Cite this article as:
Jalilian R. A., Bineshmarvasti M. and Sardari S., Application of Radioisotopes in Inflammation, Current Medicinal Chemistry 2006; 13 (8) . https://dx.doi.org/10.2174/092986706776361049
DOI https://dx.doi.org/10.2174/092986706776361049 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Optimal Treatment of Severe Community-Acquired Pneumonia
Current Respiratory Medicine Reviews Insights into the Role of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Health and Disease
Current Chemical Biology Digital Ulcers in Systemic Sclerosis – How to Manage in 2013?
Current Rheumatology Reviews Hypocholesterolemia
Current Vascular Pharmacology Coumarin and Isocoumarin as Serine Protease Inhibitors
Current Pharmaceutical Design Phenotyping of Chronic Obstructive Pulmonary Disease: Current Approaches and Future Directions
Current Respiratory Medicine Reviews Hyperuricemia: Is it a Risk Factor for Vascular Endothelial Dysfunction and Associated Cardiovascular Disorders?
Current Hypertension Reviews Addiction Liability of Pharmacotherapeutic Interventions in Obesity
Current Pharmaceutical Design Electroconvulsive Therapy in Child and Adolescent Psychiatry
Current Psychiatry Reviews Suppression of NF-κB Signaling and P-glycoprotein Function by Gambogic Acid Synergistically Potentiates Adriamycin -induced Apoptosis in Lung Cancer
Current Cancer Drug Targets Fetal Risks of Maternal Diabetes
Current Women`s Health Reviews Role of Nitric Oxide in Liver Injury
Current Molecular Medicine “The Tools of the Trade” – An Overview of the Pharmacology of the Endocannabinoid System
Current Pharmaceutical Design Modulation of Neutrophil Function by Hormones
Current Immunology Reviews (Discontinued) Breath Analysis and the Measurement of Total Body Water Using Isotope Dilution – Applications in the Dialysis Clinic
Current Analytical Chemistry Treatment Failure in Ventilator Associated Pneumonia
Current Respiratory Medicine Reviews Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare
Current Pharmaceutical Biotechnology Biological Relevance of Lysophospholipids and Green Solutions for Their Synthesis
Current Organic Chemistry Antidote Control of Aptamer Therapeutics: The Road to a Safer Class of Drug Agents
Current Pharmaceutical Biotechnology Antiplatelet Therapy in Children: Why So Different from Adults’?
Current Pharmaceutical Design