A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update

Title: A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update

Volume: 13 Issue: 4

Author(s): W. Waelput, P. Brouckaert, D. Broekaert and J. Tavernier

Affiliation:

Keywords: leptin receptor, CRH-knockout, lymphocytes, DTH reaction, pro-inflammatory mediators, Septic Shock

Abstract: Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptins biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.

Cite this article as:

Waelput W., Brouckaert P., Broekaert D. and Tavernier J., A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update, Current Medicinal Chemistry 2006; 13 (4) . https://dx.doi.org/10.2174/092986706775527929