Generic placeholder image

Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Clinical Immunity to Malaria

Author(s): Louis Schofield and Ivo Mueller

Volume 6, Issue 2, 2006

Page: [205 - 221] Pages: 17

DOI: 10.2174/156652406776055221

Price: $65

Abstract

Under appropriate conditions of transmission intensity, functional immunity to malaria appears to be acquired in distinct stages. The first phase reduces the likelihood of severe or fatal disease; the second phase limits the clinical impact of mild malaria; and the third provides partial but incomplete protection against pathogen burden [1, 2]. These findings suggest clinical immunity to mortality and morbidity is acquired earlier, with greater ease, and via distinct mechanisms as compared to anti-parasite immunity, which is more difficult to achieve, takes longer and is only ever partially efficacious. The implications of this view are significant in that current vaccination strategies aim predominantly to achieve anti-parasite immunity, although imparting clinical immunity is the public health objective. Despite enormous relevance for global public health, the mechanisms governing these processes remain obscure. Four candidate mechanisms might mediate clinical immunity, namely immunity to cytoadherence determinants, tolerance to toxins, acquired immunity to toxins, and immunoregulation. This review addresses the targets and determinants of clinical immunity, and considers the implications for vaccine development.

Keywords: chemoprophylaxis, P. falciparum transmission, Anti-parasite immunity, Variant Surface Antigens (VSAs), Cerebral Malaria, Anaemia


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy