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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Severe Malaria: Metabolic Complications

Author(s): T. Planche and S. Krishna

Volume 6, Issue 2, 2006

Page: [141 - 153] Pages: 13

DOI: 10.2174/156652406776055177

Price: $65

Abstract

Metabolic complications of severe malaria are some of the most important and potentially treatable manifestations of this deadly disease. The commonest metabolic complications (lactic acidosis and hypoglycaemia) arise from increased host anaerobic metabolism probably due to a mismatch between tissue oxygen supply and requirement. Optimising treatments for these complications should be guided by detailed understanding of their underlying pathophysiology, and may help to reduce the intolerably high case fatality rate of severe malaria.

Keywords: malaria, lactate, acidosis, hypoglycaemia, pathophysiology


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