Abstract
The full-length and four alternatively spliced variant mRNA transcripts of rat TERT were identified. One of the variant, rTERTb, was predominantly expressed during brain development in accordance with the decrease in telomerase activity. The rTERTb mRNA encoded an inactive truncated protein. Alternative splicing of TERT may be important during brain development.
Keywords: Alternative splicing, Telomerase, TERT, Brain development, Rattus norvegicus
Protein & Peptide Letters
Title: Predominant Expression of rTERTb, an Inactive TERT Variant, in the Adult Rat Brain
Volume: 13 Issue: 1
Author(s): R. Kaneko, S. Esumi, T. Yagi and T. Hirabayashi
Affiliation:
Keywords: Alternative splicing, Telomerase, TERT, Brain development, Rattus norvegicus
Abstract: The full-length and four alternatively spliced variant mRNA transcripts of rat TERT were identified. One of the variant, rTERTb, was predominantly expressed during brain development in accordance with the decrease in telomerase activity. The rTERTb mRNA encoded an inactive truncated protein. Alternative splicing of TERT may be important during brain development.
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Cite this article as:
Kaneko R., Esumi S., Yagi T. and Hirabayashi T., Predominant Expression of rTERTb, an Inactive TERT Variant, in the Adult Rat Brain, Protein & Peptide Letters 2006; 13 (1) . https://dx.doi.org/10.2174/092986606774502108
DOI https://dx.doi.org/10.2174/092986606774502108 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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