Synthetic Methodologies for the Preparation of Epothilones and Analogs

Title: Synthetic Methodologies for the Preparation of Epothilones and Analogs

Volume: 3 Issue: 1

Author(s): Inacio Luduvico, Mireille L. Hyaric, Mauro V. De Almeida and Adilson D. Da Silva

Affiliation:

Keywords: Epothilone, antitumor compounds, total synthesis

Abstract: Epothilones are natural products present in the myxobacterium Sorangium cellulossum strain 90. Due to their antitumoral activity, they are good candidates for the treatment of various forms of cancer, and epothilones B and D and some synthetic analogs are actually under advanced clinical trials. This review describes the synthesis of epothilones A and B and some of their analogs.

Cite this article as:

Luduvico Inacio, Hyaric L. Mireille, De Almeida V. Mauro and Da Silva D. Adilson, Synthetic Methodologies for the Preparation of Epothilones and Analogs, Mini-Reviews in Organic Chemistry 2006; 3 (1) . https://dx.doi.org/10.2174/157019306775474194