Abstract
The human microbial pathogen Helicobacter pylori colonises the stomach of more than half of the worlds population. The microorganism can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. Highly virulent H. pylori strains carry a cag pathogenicity island (cag PAI), which encodes proteins involved in a specialised type IV secretion system (T4SS). H. pylori induces T4SS-dependent and -independent processes by which H. pylori takes direct command of gastric epithelial cell signaling. The H. pylori effector protein cytotoxin associated gene A (CagA), which is translocated via the T4SS into epithelial cells, contributes to the modulation of cellular functions. In addition, H. pylori transactivates the EGFR, a process involving inter-receptor cross talk and extracellular ADAM metalloproteinase cleavage of membrane bound EGFR ligands. The multiple signal transduction pathways activated during H. pylori infection lead to a complex series of events promoting inappropriate inflammatory responses, epithelial hyperproliferation, epithelial survival and transformation. The H. pylori induced epithelial cellular changes, as well as chemopreventative therapeutic strategies, will be introduced in this review.
Keywords: Helicobacter pylori, CagA, epithelial proliferation, NF-kB, EGFR, ADAM metalloproteinases, c-Met
Current Signal Transduction Therapy
Title: Epithelial Cell Signaling in Helicobacter pylori Infection
Volume: 1 Issue: 1
Author(s): Jean E. Crabtree and Michael Naumann
Affiliation:
Keywords: Helicobacter pylori, CagA, epithelial proliferation, NF-kB, EGFR, ADAM metalloproteinases, c-Met
Abstract: The human microbial pathogen Helicobacter pylori colonises the stomach of more than half of the worlds population. The microorganism can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. Highly virulent H. pylori strains carry a cag pathogenicity island (cag PAI), which encodes proteins involved in a specialised type IV secretion system (T4SS). H. pylori induces T4SS-dependent and -independent processes by which H. pylori takes direct command of gastric epithelial cell signaling. The H. pylori effector protein cytotoxin associated gene A (CagA), which is translocated via the T4SS into epithelial cells, contributes to the modulation of cellular functions. In addition, H. pylori transactivates the EGFR, a process involving inter-receptor cross talk and extracellular ADAM metalloproteinase cleavage of membrane bound EGFR ligands. The multiple signal transduction pathways activated during H. pylori infection lead to a complex series of events promoting inappropriate inflammatory responses, epithelial hyperproliferation, epithelial survival and transformation. The H. pylori induced epithelial cellular changes, as well as chemopreventative therapeutic strategies, will be introduced in this review.
Export Options
About this article
Cite this article as:
Crabtree E. Jean and Naumann Michael, Epithelial Cell Signaling in Helicobacter pylori Infection, Current Signal Transduction Therapy 2006; 1 (1) . https://dx.doi.org/10.2174/157436206775269253
DOI https://dx.doi.org/10.2174/157436206775269253 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Naturally Occurring Methyl Salicylate Glycosides
Mini-Reviews in Medicinal Chemistry The Complex Airway in Childhood Asthma
Current Pediatric Reviews Is There a Role for Antioxidants in the Prevention of Infection-Associated Carcinogenesis and in the Treatment of Infection-Driven Tumors?
Current Topics in Medicinal Chemistry Profiling and Characterization of microRNAs Responding to Sodium Butyrate Treatment in Gastric Cancer Cells
Combinatorial Chemistry & High Throughput Screening Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
Current Genomics Recent Patents on Antibacterial, Antifungal and Antiviral Properties of Tea
Recent Patents on Anti-Infective Drug Discovery ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents
Recent Patents on Anti-Cancer Drug Discovery Current Advances and Therapeutic Potential of Agents Targeting Dipeptidyl Peptidases-IV, -II, 8/9 and Fibroblast Activation Protein
Current Topics in Medicinal Chemistry Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update
Current Medicinal Chemistry Tubulin Inhibitors: A Patent Survey
Recent Patents on Anti-Cancer Drug Discovery Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents
Current Drug Targets Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors
Current Topics in Medicinal Chemistry High Expression of Human Leukocyte Antigen-G is Associated with a Poor Prognosis in Patients with PDAC
Current Molecular Medicine TGF-Beta: a Master Switch in Tumor Immunity
Current Pharmaceutical Design Cancer “Stemness”- Regulating MicroRNAs: Role, Mechanisms and Therapeutic Potential
Current Drug Targets Mycotoxins Levels in Human Milk: A Menace to Infants and Children Health
Current Nutrition & Food Science Cardiovascular Toxicity from the Perspective of Oxidative Stress, Electron Transfer, and Prevention by Antioxidants
Current Vascular Pharmacology Involvement of the Transforming Growth Factor β in the Pathogenesis of Hereditary Hemorrhagic Telangiectasia
Current Pharmaceutical Design Opportunities and Challenges of Fluorescent Carbon Dots in Translational Optical Imaging
Current Pharmaceutical Design Women and Drug and Alcohol Use Disorders: Compounding the Picture with Severe Mental Illness
Current Women`s Health Reviews