Abstract
Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to interact with more than one target, gained particular attention, in an attempt to find new drugs in a shorter time with respect to other strategies. These structures, that have been identified mainly by empirical observations, can target only a given protein family, or can be able to interact with more, unrelated targets. This review deals with structures not covered in recent papers on this topic, and emphasizes the importance of understanding the structure-target relationships, that confer the privileged status.
Keywords: Privileged structures, drug discovery, carbohydrates, benzodiazepines, biphenyls, pyrrolinones
Current Medicinal Chemistry
Title: Privileged Structures as Leads in Medicinal Chemistry
Volume: 13 Issue: 1
Author(s): Luca Costantino and Daniela Barlocco
Affiliation:
Keywords: Privileged structures, drug discovery, carbohydrates, benzodiazepines, biphenyls, pyrrolinones
Abstract: Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to interact with more than one target, gained particular attention, in an attempt to find new drugs in a shorter time with respect to other strategies. These structures, that have been identified mainly by empirical observations, can target only a given protein family, or can be able to interact with more, unrelated targets. This review deals with structures not covered in recent papers on this topic, and emphasizes the importance of understanding the structure-target relationships, that confer the privileged status.
Export Options
About this article
Cite this article as:
Costantino Luca and Barlocco Daniela, Privileged Structures as Leads in Medicinal Chemistry, Current Medicinal Chemistry 2006; 13 (1) . https://dx.doi.org/10.2174/092986706775197999
DOI https://dx.doi.org/10.2174/092986706775197999 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Noninvasive Monitoring of Intracranial Pressure
Recent Patents on Biomedical Engineering (Discontinued) Endothelial Dysfunction and Atherosclerosis: Focus on Novel Therapeutic Approaches
Recent Patents on Cardiovascular Drug Discovery 4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents
Mini-Reviews in Medicinal Chemistry Biodiversity as a Source of Bioactive Compounds Against Snakebites
Current Medicinal Chemistry Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential
Current Neuropharmacology Indoles - Gut Bacteria Metabolites of Tryptophan with Pharmacotherapeutic Potential
Current Drug Metabolism Ghrelin and Cardiovascular Diseases
Current Cardiology Reviews Topotecan Is a Substrate for Multidrug Resistance Associated Protein 4
Current Drug Metabolism Identifying User Suitability in sEMG Based Hand Prosthesis Using Neural Networks
Current Signal Transduction Therapy A Review on the Use of Statins and Tocotrienols, Individually or in Combination for the Treatment of Osteoporosis
Current Drug Targets Green Tea, A Medicinal Food with Promising Neurological Benefits
Current Neuropharmacology Cerebral Malaria - A Neurovascular Pathology with Many Riddles Still to be Solved
Current Neurovascular Research Current Advances in Therapy for Metastatic Melanoma
Current Cancer Therapy Reviews The Current Role and Therapeutic Targets of Vitamin D in Gastrointestinal Inflammation and Cancer
Current Pharmaceutical Design Wharton's Jelly Mesenchymal Stem Cell Response on Chitosan-graft-poly (ε-caprolactone) Copolymer for Myocardium Tissue Engineering
Current Pharmaceutical Design Current Status of Renal Arterial Endovascular Interventions
Current Hypertension Reviews Tartaric Acid Enhances Adrenergic Receptor Activity: Test of a General Theory of Extracellular Aminergic GPCR Enhancer Discovery
Current Drug Discovery Technologies The Complex Actions of Statins in Brain and their Relevance for Alzheimer`s Disease Treatment: An Analytical Review
Current Alzheimer Research Nanocarriers for Anticancer Drugs - New Trends in Nanomedicine
Current Drug Metabolism Obesity and Metabolic Syndrome Affect the Cholinergic Transmission a nd Cognitive Functions
CNS & Neurological Disorders - Drug Targets