Abstract
Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression
Current Molecular Medicine
Title: The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins
Volume: 6 Issue: 1
Author(s): Scott A. Oakes, Stephen S. Lin and Michael C. Bassik
Affiliation:
Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression
Abstract: Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
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Cite this article as:
Oakes A. Scott, Lin S. Stephen and Bassik C. Michael, The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins, Current Molecular Medicine 2006; 6 (1) . https://dx.doi.org/10.2174/156652406775574587
DOI https://dx.doi.org/10.2174/156652406775574587 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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