Abstract
Management of pain and anxiety for children requiring urgent care has progressed dramatically in the past decade. However, the administration of analgesia and sedation in children is inconsistent, with significant practice variation among practitioners, and especially amid younger children who receive less than optimal analgesia. Nasal administrations of drugs have several significant advantages over current practices. The nose has a very rich vascular supply, it facilitates direct absorption to the systemic blood supply and increases bioavailability of the drug, compared to oral administration. The current review summarizes available information on the use of intranasal drug delivery for children in acute illness. Midazolam (Versed), Fentanyl, Diamorphine and Ketamine are discussed, as well as pitfalls and caveats of intranasal drug use.
Keywords: bioavailability, nasal cavity, Drug delivery, controlled trails, Benzodiazepins, Intranasal fentanyl
Current Drug Therapy
Title: Intranasal Drug Delivery for Children with Acute Illness
Volume: 1 Issue: 1
Author(s): Ran D. Goldman
Affiliation:
Keywords: bioavailability, nasal cavity, Drug delivery, controlled trails, Benzodiazepins, Intranasal fentanyl
Abstract: Management of pain and anxiety for children requiring urgent care has progressed dramatically in the past decade. However, the administration of analgesia and sedation in children is inconsistent, with significant practice variation among practitioners, and especially amid younger children who receive less than optimal analgesia. Nasal administrations of drugs have several significant advantages over current practices. The nose has a very rich vascular supply, it facilitates direct absorption to the systemic blood supply and increases bioavailability of the drug, compared to oral administration. The current review summarizes available information on the use of intranasal drug delivery for children in acute illness. Midazolam (Versed), Fentanyl, Diamorphine and Ketamine are discussed, as well as pitfalls and caveats of intranasal drug use.
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Cite this article as:
Goldman D. Ran, Intranasal Drug Delivery for Children with Acute Illness, Current Drug Therapy 2006; 1 (1) . https://dx.doi.org/10.2174/157488506775268470
DOI https://dx.doi.org/10.2174/157488506775268470 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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