Abstract
The pathogenesis and clinical significance of cerebral white matter lesions (WML) remain controversial. Various studies have shown that age, hypertension, diabetes mellitus and a history of stroke or heart disease are the most important factors related to cerebral WML. Other studies suggest that WML are closely related to the development of future strokes and other forms of cerebrovascular disease, such as cognitive impairment, in elderly patients with vascular risk factors, particularly hypertension. Angiotensin receptor blockers are antihypertensive drugs useful for the treatment of hypertension and cardiovascular diseases. Recent data from experimental studies and clinical trials suggest that they could be superior to other antihypertensive therapies in preventing the development of cerebrovascular disease and in reducing the risk of death and recurrences in patients with a previous stroke. This paper reviews the clinical importance of cerebral WML, their relationship with stroke development and data concerning cerebrovascular protection with angiotensin receptor blockers.
Keywords: Cerebral white matter lesions, stroke, angiotensin receptor blockers, hypertension, cerebrovascular disease
Current Drug Therapy
Title: Cerebral White Matter Lesions, Risk of Stroke and Cerebrovascular Protection with Angiotensin Receptor Blockers
Volume: 1 Issue: 1
Author(s): Alejandro d. l. Sierra and Cristina Sierra
Affiliation:
Keywords: Cerebral white matter lesions, stroke, angiotensin receptor blockers, hypertension, cerebrovascular disease
Abstract: The pathogenesis and clinical significance of cerebral white matter lesions (WML) remain controversial. Various studies have shown that age, hypertension, diabetes mellitus and a history of stroke or heart disease are the most important factors related to cerebral WML. Other studies suggest that WML are closely related to the development of future strokes and other forms of cerebrovascular disease, such as cognitive impairment, in elderly patients with vascular risk factors, particularly hypertension. Angiotensin receptor blockers are antihypertensive drugs useful for the treatment of hypertension and cardiovascular diseases. Recent data from experimental studies and clinical trials suggest that they could be superior to other antihypertensive therapies in preventing the development of cerebrovascular disease and in reducing the risk of death and recurrences in patients with a previous stroke. This paper reviews the clinical importance of cerebral WML, their relationship with stroke development and data concerning cerebrovascular protection with angiotensin receptor blockers.
Export Options
About this article
Cite this article as:
Sierra d. l. Alejandro and Sierra Cristina, Cerebral White Matter Lesions, Risk of Stroke and Cerebrovascular Protection with Angiotensin Receptor Blockers, Current Drug Therapy 2006; 1 (1) . https://dx.doi.org/10.2174/157488506775268452
DOI https://dx.doi.org/10.2174/157488506775268452 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The TOLL-like / Type-I Interferon Pathways as Emerging Therapeutic Targets for Autoimmune Diseases
Drug Design Reviews - Online (Discontinued) New Hybrid Method for Left Ventricular Ejection Fraction Assessment from Radionuclide Ventriculography Images
Current Medical Imaging Current Hot Potatoes in Atrial Fibrillation Ablation
Current Cardiology Reviews Non Peptidic Urotensin II Antagonists: Perspectives for a New Class of Drugs
Cardiovascular & Hematological Agents in Medicinal Chemistry Tetralogy of Fallot and Hypoplastic Left Heart Syndrome – Complex Clinical Phenotypes Meet Complex Genetic Networks
Current Genomics The Role of Cellular Senescence During Vascular Calcification: A Key Paradigm in Aging Research
Current Aging Science Development of Meat and Poultry Products Enriched with n-3 PUFAs and their Functional Role
Current Nutrition & Food Science Neuro-Psychological Pattern in Patients Suffering from Primitive Dilated Cardiomyopathy with Impairment in Executive Function
Current Neurovascular Research Desmoteplase for Acute Ischemic Stroke: A Systematic Review and Metaanalysis of Randomized Controlled Trials
CNS & Neurological Disorders - Drug Targets Recent Advances in Nanoparticle Carriers for Coordination Complexes
Current Topics in Medicinal Chemistry Curative Effects of <i>Dhatryadi ghrita</i> Bioactive Extracts on Ethanol Withdrawal Syndrome in Wistar Rats
Current Bioactive Compounds Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques
Current Drug Metabolism Cyclodextrins as Food Additives and in Food Processing
Current Nutrition & Food Science Trials Comparing Percutaneous And Surgical Myocardial Revascularization: A Review
Reviews on Recent Clinical Trials Ezetimibe and Vascular Endothelial Function
Current Vascular Pharmacology Should We be Concerned About the Inflammatory Response to Endovascular Procedures?
Current Vascular Pharmacology The Role of Estrogen and Estrogen-Related Drugs in Cardiovascular Diseases
Current Drug Metabolism Arterial Thickness and Immunometabolism: The Mediating role of Chronic Exercise
Current Cardiology Reviews Harnessing the Potential of Long Non-coding RNAs to Manage Metabolic Diseases
Current Pharmaceutical Design Antioxidants in Peripheral Arterial Disease
Current Drug Targets - Cardiovascular & Hematological Disorders