Abstract
Derangement of glucose metabolism is a key feature of T2DM, with the liver and pancreatic β-cells playing a key role in glucose homeostasis. In the postprandial state, glucose is transported into hepatocytes and either metabolized to fatty acids or CO2, or stored as glycogen. Glucose also acts as a key signal in pancreatic β-cells for regulating insulin secretion. Because GLUT2 and GK expressed in liver and β-cells are responsible for sensing glucose levels in the blood, studies on the regulation of these biomolecules are important in understanding glucose homeostasis in vivo. These molecules are known to be regulated either transcriptionally or post-transcriptionally, and recent studies on the structure and function of promoters of these genes have revealed the involvement of various transcriptional factors in their regulation. Here, we review recent progress in elucidating the transcriptional regulation of glucose sensors in the liver and pancreatic β-cells and the relevance to T2DM.
Keywords: Type 2 glucose transporter isoform (GLUT2), Glucokinase (GK), Glucose sensor, Transcription, Liver, Pancreatic βcells
Current Diabetes Reviews
Title: Transcriptional Regulation of Glucose Sensors in Pancreatic β Cells and Liver
Volume: 2 Issue: 1
Author(s): Seung-Soon Im, So-Youn Kim, Ha-il Kim and Yong-Ho Ahn
Affiliation:
Keywords: Type 2 glucose transporter isoform (GLUT2), Glucokinase (GK), Glucose sensor, Transcription, Liver, Pancreatic βcells
Abstract: Derangement of glucose metabolism is a key feature of T2DM, with the liver and pancreatic β-cells playing a key role in glucose homeostasis. In the postprandial state, glucose is transported into hepatocytes and either metabolized to fatty acids or CO2, or stored as glycogen. Glucose also acts as a key signal in pancreatic β-cells for regulating insulin secretion. Because GLUT2 and GK expressed in liver and β-cells are responsible for sensing glucose levels in the blood, studies on the regulation of these biomolecules are important in understanding glucose homeostasis in vivo. These molecules are known to be regulated either transcriptionally or post-transcriptionally, and recent studies on the structure and function of promoters of these genes have revealed the involvement of various transcriptional factors in their regulation. Here, we review recent progress in elucidating the transcriptional regulation of glucose sensors in the liver and pancreatic β-cells and the relevance to T2DM.
Export Options
About this article
Cite this article as:
Im Seung-Soon, Kim So-Youn, Kim Ha-il and Ahn Yong-Ho, Transcriptional Regulation of Glucose Sensors in Pancreatic β Cells and Liver, Current Diabetes Reviews 2006; 2 (1) . https://dx.doi.org/10.2174/157339906775473581
DOI https://dx.doi.org/10.2174/157339906775473581 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus
Current Drug Targets Oral Mucosa for Delivery of Drugs, Allergens and Vaccines: Where are we Now?
Current Drug Delivery PPAR Ligands Containing Stilbene Scaffold
Mini-Reviews in Medicinal Chemistry New Trends in Thromboxane and Prostacyclin Modulators
Current Medicinal Chemistry ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update
Current Pharmaceutical Design Consequences of Secondary Hyperparathyroidism on Vascular Calcification and Cardiovascular Mortality: Potential Benefit of Calcimimetics
Current Drug Therapy Live Yeast Cell Derivative Induces c-fos Expression in THP-1 Monocytes
Medicinal Chemistry CD26: A Multi-Purpose Pharmacological Target
Current Clinical Pharmacology Different Pharmacokinetic Responses to an Acute Dose of Inorganic Nitrate in Patients with Type 2 Diabetes
Endocrine, Metabolic & Immune Disorders - Drug Targets Multiple Defects in Energy Metabolism in Alzheimers Disease
Current Drug Targets Endothelial Dysfunction: Methods of Assessment and Application to Hypertension
Current Pharmaceutical Design Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease
Current Vascular Pharmacology Angiotensin II in Type 2 Diabetes Mellitus
Current Protein & Peptide Science Simultaneous Determination of Saponins and Lignans in Rat Plasma by UPLC- MS/MS and its Application to a Pharmacokinetic Study of Shenqi Jiangtang Granule
Current Drug Metabolism Omentin: Linking Metabolic Syndrome and Cardiovascular Disease
Current Vascular Pharmacology Protein Crystallography in Drug Discovery
Current Drug Targets Is the Use of Autologous Platelet-Rich Plasma Gels in Gynecologic, Cardiac, and General, Reconstructive Surgery Beneficial?
Current Pharmaceutical Biotechnology Myocardial Infarction. Pathological Relevance and Relationship with Coronary Risk Factors
Current Pharmaceutical Design TiO2-Nanowired Delivery of Mesenchymal Stem Cells Thwarts Diabetes- Induced Exacerbation of Brain Pathology in Heat Stroke: An Experimental Study in the Rat Using Morphological and Biochemical Approaches
CNS & Neurological Disorders - Drug Targets The Epidemiology of Sepsis
Current Pharmaceutical Design