Abstract
Thalidomide ([2-(2,6-dioxo-hexahydro-3-(R,S)-pyridinyl)-1,3-isoindolinedione]), well known by its teratogenic effect, caused birth defects in up to 12,000 children in the 1960s. More recently, this drug was approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum, under restricted-use program, and a variety of new possible therapeutic applications have been described. This article will accomplish a review of medicinal chemistry aspects of thalidomide and state of the art in the development of new anti-inflammatory and immunomodulator drug candidates designed using thalidomide as lead-compound.
Keywords: CYP450, Teratogenicity, bioactivation, thiothalidomide analogs, CoMFA, cAMP
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates
Volume: 5 Issue: 1
Author(s): Lidia M. Lima, Carlos A. Manssour Fraga, Vera L. Goncalves Koatz and Eliezer J. Barreiro
Affiliation:
Keywords: CYP450, Teratogenicity, bioactivation, thiothalidomide analogs, CoMFA, cAMP
Abstract: Thalidomide ([2-(2,6-dioxo-hexahydro-3-(R,S)-pyridinyl)-1,3-isoindolinedione]), well known by its teratogenic effect, caused birth defects in up to 12,000 children in the 1960s. More recently, this drug was approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum, under restricted-use program, and a variety of new possible therapeutic applications have been described. This article will accomplish a review of medicinal chemistry aspects of thalidomide and state of the art in the development of new anti-inflammatory and immunomodulator drug candidates designed using thalidomide as lead-compound.
Export Options
About this article
Cite this article as:
Lima M. Lidia, Manssour Fraga A. Carlos, Goncalves Koatz L. Vera and Barreiro J. Eliezer, Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2006; 5 (1) . https://dx.doi.org/10.2174/187152306775537328
DOI https://dx.doi.org/10.2174/187152306775537328 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Insulin Therapy in Pregnancy Hypertensive Diseases and its Effect on the Offspring and Mother Later in Life
Current Vascular Pharmacology Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)
Current Alzheimer Research Diabetes Mellitus to Neurodegenerative Disorders: Is Oxidative Stress Fueling the Flame?
CNS & Neurological Disorders - Drug Targets Metabolic Syndrome in HIV-patients in Antiretroviral Therapy
Current HIV Research Nucleoside Transporter Proteins
Current Vascular Pharmacology Gold Nanoparticles - Synthesis and Applications in Cancer Management
Recent Patents on Materials Science Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review
Current Medicinal Chemistry Hypertension, Cognitive Impairment and Dementia: An Epidemiological Perspective
Current Hypertension Reviews Subject Index to Volume 2
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Unusual Food Allergy: AlioideaAllergic Reactions Overview
Recent Patents on Inflammation & Allergy Drug Discovery Dyslipidaemia, Hypercoagulability and the Metabolic Syndrome
Current Vascular Pharmacology Antiplatelet and Anticoagulation Strategies in the Prevention and Treatment of Ischemic Stroke
Current Pharmaceutical Design N-Acetylcysteine for the Treatment of Obsessive-Compulsive Disorder
Current Psychiatry Reviews Biologics: An Update and Challenge of Their Pharmacokinetics
Current Drug Metabolism Crocin Protects Human Umbilical Vein Endothelial Cells from High Glucose-Induced Injury Via Inhibiting the Endoplasmic Reticulum Stress Response
Current Molecular Medicine Effects of Thiazolidinediones Beyond Glycaemic Control
Current Pharmaceutical Design Increasing High-Density Lipoprotein Cholesterol Through Cholesteryl Ester Transfer Protein Inhibition: A Next Step in the Fight Against Cardiovascular Disease?
Current Drug Targets - Cardiovascular & Hematological Disorders Metabolic Syndrome Racial Differences in Adolescents
Current Diabetes Reviews The Burden of Metabolic Diseases Amongst HIV Positive Patients on HAART Attending the Johannesburg Hospital
Current HIV Research The Interplay of Marine Exposure in Gestational Diabetes
Current Women`s Health Reviews