Abstract
Thalidomide ([2-(2,6-dioxo-hexahydro-3-(R,S)-pyridinyl)-1,3-isoindolinedione]), well known by its teratogenic effect, caused birth defects in up to 12,000 children in the 1960s. More recently, this drug was approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum, under restricted-use program, and a variety of new possible therapeutic applications have been described. This article will accomplish a review of medicinal chemistry aspects of thalidomide and state of the art in the development of new anti-inflammatory and immunomodulator drug candidates designed using thalidomide as lead-compound.
Keywords: CYP450, Teratogenicity, bioactivation, thiothalidomide analogs, CoMFA, cAMP
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates
Volume: 5 Issue: 1
Author(s): Lidia M. Lima, Carlos A. Manssour Fraga, Vera L. Goncalves Koatz and Eliezer J. Barreiro
Affiliation:
Keywords: CYP450, Teratogenicity, bioactivation, thiothalidomide analogs, CoMFA, cAMP
Abstract: Thalidomide ([2-(2,6-dioxo-hexahydro-3-(R,S)-pyridinyl)-1,3-isoindolinedione]), well known by its teratogenic effect, caused birth defects in up to 12,000 children in the 1960s. More recently, this drug was approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum, under restricted-use program, and a variety of new possible therapeutic applications have been described. This article will accomplish a review of medicinal chemistry aspects of thalidomide and state of the art in the development of new anti-inflammatory and immunomodulator drug candidates designed using thalidomide as lead-compound.
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Cite this article as:
Lima M. Lidia, Manssour Fraga A. Carlos, Goncalves Koatz L. Vera and Barreiro J. Eliezer, Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2006; 5 (1) . https://dx.doi.org/10.2174/187152306775537328
DOI https://dx.doi.org/10.2174/187152306775537328 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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