Prevention of Oxidative Stress and Diseases by Antioxidant
Supplementation

Giovanni      Martemucci; Piero      Portincasa; Vincenzo      Centonze; Michele      Mariano; Mohamad      Khalil; Angela   Gabriella   D'Alessandro
Abstract

Excessive and uncontrolled oxidative stress can damage biomacromolecules, such as lipids, proteins, carbohydrates, and DNA, by free radical and oxidant overproduction. In this review, we critically discuss the main properties of free radicals, their implications in oxidative stress, and specific pathological conditions. In clinical medicine, oxidative stress can play a role in several chronic noncommunicable diseases, such as diabetes mellitus, cardiovascular, inflammatory, neurodegenerative diseases, and tumours. Antioxidant supplements can theoretically prevent or stop the progression of diseases, but a careful literature analysis finds that more evidence is needed to dissect the ultimate beneficial effect of antioxidants versus reactive oxygen species in several diseases.
Keywords: Free radicals, oxidative stress, antioxidants, oxidative damage, diseases, reactive oxygen species.
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DOI https://dx.doi.org/10.2174/1573406419666221130162512	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638
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