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Current Medicinal Chemistry

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General Review Article

The Association Between the Risk of Breast Cancer and Epigallocatechin- 3-Gallate Intake: A Literature Review of a Potential Chemopreventive Agent

Author(s): Efstratios Athanasiou*, Georgios-Ioannis Verras, Savvas Papageorgiou, Ioannis Kelesis, Athanasios Gatsis, Christina Karaoulani, Ioannis Stouras, Panagiotis Kanatas, Elmina-Marina Saitani, Maria-Eleni Oikonomou, Danae-Anastasia Vlassi, Maria Vasileiou, Christos Tsagkaris, Athanasios Alexiou and Mohammad Amjad Kamal

Volume 29, Issue 40, 2022

Published on: 27 August, 2022

Page: [6169 - 6196] Pages: 28

DOI: 10.2174/0929867329666220726153412

Price: $65

Abstract

According to the latest epidemiological data, breast cancer has recently been the most frequently diagnosed malignancy. To date, a body of evidence has established the involvement of multiple - and frequently interrelated - genetic and environmental factors in the pathogenesis of the disease. Emerging research on cancer prevention has highlighted the deterrence potential of interventions targeting environmental risk factors, particularly diet. In this aspect, the current review reveals the latest scientific results regarding epigallocatechin-3-gallate (EGCG) - a catechin most commonly found in green tea, as a potential chemopreventive dietary agent against breast cancer. in vitro studies on EGCG have demonstrated its effect on cell cycle progression and its potential to suppress several intracellular signaling pathways involved in breast cancer pathogenesis. In addition, EGCG possesses specific apoptosis-inducing characteristics that seem to enhance its role as a regulator of cell survival. Preclinical data seem to support using EGCG as an effective adjunct to EGFR-targeting treatments. The authors’ appraisal of the literature suggests that although preclinical evidence has documented the anticarcinogenic features of EGCG, limited large-scale epidemiological studies are investigating the consumption of EGCG - containing nutrients in the prevention and management of breast cancer risk. This literature review aims to liaise between preclinical and epidemiological research, surveying the existing evidence and unraveling relevant knowledge gaps.

Keywords: Epigallocatechin-3-gallate, breast cancer, chemoprevention, green tea, natural products, antioxidant properties, and anti-inflammatory properties.

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