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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Perspective

Antibiotics’ Sustainability: Another Issue in the Fight against Antimicrobial Resistance

Author(s): Silvia Buroni and Laurent R. Chiarelli*

Volume 22, Issue 24, 2022

Published on: 24 June, 2022

Page: [1979 - 1981] Pages: 3

DOI: 10.2174/1568026622666220516114647

Abstract

The spread of antimicrobial resistance (AMR) is still a major threat to global health that is likely to worsen also as a consequence of the COVID-19 pandemic. For this reason, there is an urgent need to develop new compounds and novel alternative treatments. Furthermore, the new lines of action must consider the issue of antibiotics’ sustainability. Within this persrective, we have highlighted the main points on which actions in this perspective are possible.

Keywords: Antibiotics, Antibiotics management, Antibiotics removal, Antibiotics resistance, Green chemistry, Sustainability.

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Graphical Abstract
[1]
Miethke, M.; Pieroni, M.; Weber, T.; Brönstrup, M.; Hammann, P.; Halby, L.; Arimondo, P.B.; Glaser, P.; Aigle, B.; Bode, H.B.; Moreira, R.; Li, Y.; Luzhetskyy, A.; Medema, M.H.; Pernodet, J.L.; Stadler, M.; Tormo, J.R.; Genilloud, O.; Truman, A.W.; Weissman, K.J.; Takano, E.; Sabatini, S.; Stegmann, E.; Brötz-Oesterhelt, H.; Wohlleben, W.; Seemann, M.; Empting, M.; Hirsch, A.K.H.; Loretz, B.; Lehr, C.M.; Titz, A.; Herrmann, J.; Jaeger, T.; Alt, S.; Hesterkamp, T.; Winterhalter, M.; Schiefer, A.; Pfarr, K.; Hoerauf, A.; Graz, H.; Graz, M.; Lindvall, M.; Ramurthy, S.; Karlén, A.; van Dongen, M.; Petkovic, H.; Keller, A.; Peyrane, F.; Donadio, S.; Fraisse, L.; Piddock, L.J.V.; Gilbert, I.H.; Moser, H.E.; Müller, R. Towards the sustainable discovery and development of new antibiotics. Nat. Rev. Chem., 2021, 19, 726-749.
[2]
Getahun, H.; Smith, I.; Trivedi, K.; Paulin, S.; Balkhy, H.H. Tackling antimicrobial resistance in the COVID-19 pandemic. Bull. World Health Organ., 2020, 98(7), 442.
[http://dx.doi.org/10.2471/BLT.20.268573] [PMID: 32742026]
[3]
Goyal, R.; Sharma, A.; Thakur, V.K.; Ola, M.; Sharma, P.C. Green chemistry approaches towards the design and synthesis of anti-infective fluoroquinolone derivatives. Curr. Res. Green Sustain. Chem., 2021, 4, 100044.
[http://dx.doi.org/10.1016/j.crgsc.2020.100044]
[4]
Guillemard, L.; Kaplaneris, N. Ackermann, L.; Johansson, M.J.; Late-stage C–H functionalization offers new opportunities in drug discovery. Nat. Rev. Chem., 2021, 5, 522-545.
[http://dx.doi.org/10.1038/s41570-021-00300-6]
[5]
Lasso, J.D.; Castillo-Pazos, D.J.; Li, C.J. Green chemistry meets medicinal chemistry: A perspective on modern metal-free late-stage functionalization reactions. Chem. Soc. Rev., 2021, 50(19), 10955-10982.
[http://dx.doi.org/10.1039/D1CS00380A] [PMID: 34382989]
[6]
D’Costa, V.M.; King, C.E.; Kalan, L.; Morar, M.; Sung, W.W.; Schwarz, C.; Froese, D.; Zazula, G.; Calmels, F.; Debruyne, R.; Golding, G.B.; Poinar, H.N.; Wright, G.D. Antibiotic resistance is ancient. Nature, 2011, 477(7365), 457-461.
[http://dx.doi.org/10.1038/nature10388] [PMID: 21881561]
[7]
González-Plaza, J.J.; Blau, K. Milaković M.; Jurina, T.; Smalla, K.; Udiković-Kolić N. Antibiotic-manufacturing sites are hot-spots for the release and spread of antibiotic resistance genes and mobile genetic elements in receiving aquatic environments. Environ. Int., 2019, 130, 104735.
[http://dx.doi.org/10.1016/j.envint.2019.04.007] [PMID: 31260930]
[8]
Bengtsson-Palme, J.; Milakovic, M.; Švecová, H.; Ganjto, M.; Jonsson, V.; Grabic, R.; Udikovic-Kolic, N. Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities. Water Res., 2019, 162, 437-445.
[http://dx.doi.org/10.1016/j.watres.2019.06.073] [PMID: 31301473]
[9]
Grehs, B.W.N.; Linton, M.A.O.; Clasen, B.; de Oliveira Silveira, A.; Carissimi, E. Antibiotic resistance in wastewater treatment plants: Understanding the problem and future perspectives. Arch. Microbiol., 2021, 203(3), 1009-1020.
[http://dx.doi.org/10.1007/s00203-020-02093-6] [PMID: 33112995]
[10]
Leiva. A-M-; Piña. B-; Vidal, G.; Antibiotic resistance dissemination in wastewater treatment plants: a challenge for the reuse of treated wastewater in agriculture. Rev. Environ. Sci. Biotechnol., 2021, 20, 1043-1072.
[http://dx.doi.org/10.1007/s11157-021-09588-8]
[11]
Russell, J.N.; Yost, C.K. Alternative, environmentally conscious approaches for removing antibiotics from wastewater treatment systems. Chemosphere, 2021, 263, 128177.
[http://dx.doi.org/10.1016/j.chemosphere.2020.128177] [PMID: 33297145]
[12]
Baaloudj, O.; Assadi, I.; Nasrallah, N.; El Jery, A.; Khezami, L.; Assadi, A.A. Simultaneous removal of antibiotics and inactivation of antibiotic-resistant bacteria by photocatalysis: A review. J. Water Process Eng., 2021, 42, 102089.
[http://dx.doi.org/10.1016/j.jwpe.2021.102089]
[13]
Khan, A.H.; Khan, N.A.; Zubair, M.; Azfar Shaida, M.; Manzar, M.S.; Abutaleb, A.; Naushad, M.; Iqbal, J. Sustainable green nanoadsorbents for remediation of pharmaceuticals from water and wastewater: A critical review. Environ. Res., 2022, 204(Pt C), 112243.
[http://dx.doi.org/10.1016/j.envres.2021.112243] [PMID: 34688648]
[14]
Bavumiragira, J.P.; Ge, J.; Yin, H. Fate and transport of pharmaceuticals in water systems: A processes review. Sci. Total Environ., 2022, 823, 153635.
[http://dx.doi.org/10.1016/j.scitotenv.2022.153635] [PMID: 35124044]

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