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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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Review Article

Berberine: Is it a Promising Agent for Mental Disorders Treatment?

Author(s): Mehran Shayganfard*

Volume 16, Issue 3, 2023

Published on: 07 September, 2022

Article ID: e090522204493 Pages: 14

DOI: 10.2174/1874467215666220509213122

Price: $65

Abstract

Effective and better-tolerated agents for the treatment of most of psychiatric disorders are one of the main challenges. Recently, anti-inflammatory, antioxidants and neuroprotective agents as adjuvant therapy have been shown to be able to play a role against the degenerative mechanisms commonly related to psychiatric conditions. Berberine, a biologically active alkaloid derived from various plants, represents many pharmacological impacts, such as antimicrobial, antidiabetic, anticancer, antioxidant and anti-inflammatory activities. This compound also protects neurons and improves the survival, growth and action of nerve cells due to its high potential for crossing the blood-brain barrier. Ample evidence reported that berberine had been associated with CNS-related disorders, including Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety. Thus, in this review, we aimed to indicate the effectiveness of berberine on mental disorders

Keywords: Berberine, anxiety, depression, schizophrenia, Alzheimer’s disease, neurodegenerative disease.

Graphical Abstract

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