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Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Systematic Review Article

Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review

Author(s): Nanditha Venkatesan*, Mallika Gyawali, Rinky A. Botleroo, Rowan Ahmed, Roaa Kareem, Opemipo D. Ogeyingbo, Renu Bhandari and Abeer O. Elshaikh

Volume 18, Issue 4, 2022

Published on: 26 April, 2022

Page: [317 - 328] Pages: 12

DOI: 10.2174/1573397118666220307122152

Price: $65

Abstract

Background: Fibromyalgia syndrome is characterised by extensive muscular pain and chronic fatigue. Among the pharmacologic and other nutrient supplements that have been studied, Vitamin D has garnered attention owing to the critical role it plays in inflammatory and pain pathways. We conducted a systematic literature review to examine the efficacy of vitamin D supplementation in improving the clinical status of the patients and alleviating the symptoms of fibromyalgia.

Methods: We searched Cochrane CENTRAL, PubMed, Science Direct, Scopus, grey literature (medrXiv and biorXiv) for observational studies, randomized controlled trials, case-control studies, and case reports published in English from January 2011 to May 2021, using the terms vitamin D and fibromyalgia or FMS. References were reviewed manually and articles were only included if they were specific about the diagnosis of fibromyalgia.

Results: 2651 studies were retrieved, with 12 studies fulfilling the inclusion criteria. 11 out of these 12 studies were of high quality and showed low risk of bias. 11 of these also demonstrated definitive improvement in clinical status and various outcome measures following supplementation with Vitamin D.

Conclusion: Our study emphasises an association between supplementation of vitamin D and improvement of the clinical condition of fibromyalgia through a systematic review of high-quality studies. The study also identified areas for future scope for research needed for standardising the detection and treatment of this chronic condition through cost-effective supplements such as Vitamin D.

Keywords: Cholecalciferol, chronic pain, fibromyalgia, FMS, review, vitamin D.

[1]
Abokrysha NT. Vitamin D deficiency in women with fibromyalgia in Saudi Arabia. Pain Med 2012; 13(3): 452-8.
[http://dx.doi.org/10.1111/j.1526-4637.2011.01304.x] [PMID: 22221390]
[2]
Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 1990; 33(2): 160-72.
[http://dx.doi.org/10.1002/art.1780330203] [PMID: 2306288]
[3]
Okyay R, Kocyigit BF, Gursoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Mediter 2016; 32: 243-7.
[4]
Elaziz Labeeb A, Al-Sharaki D. Detection of serum 25(OH)-vitamin D level in the serum of women with fibromyalgia syndrome and its relation to pain severity. Egypt Rheumatol Rehabil 2015; 42(4): 196-200.
[http://dx.doi.org/10.4103/1110-161X.168202]
[5]
Wolfe F, Clauw DJ, Fitzcharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 2010; 62(5): 600-10.
[http://dx.doi.org/10.1002/acr.20140] [PMID: 20461783]
[6]
Arnold LM, Clauw DJ, Dunegan LJ, Turk DC. A framework for fibromyalgia management for primary care providers. Mayo Clin Proc 2012; 87(5): 488-96.
[http://dx.doi.org/10.1016/j.mayocp.2012.02.010] [PMID: 22560527]
[7]
Bergman S. Management of musculoskeletal pain. Best Pract Res Clin Rheumatol 2007; 21(1): 153-66.
[http://dx.doi.org/10.1016/j.berh.2006.10.001] [PMID: 17350550]
[8]
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 2003; 78(12): 1463-70.
[http://dx.doi.org/10.4065/78.12.1463] [PMID: 14661675]
[9]
Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. Int J Mol Sci 2017; 18(10): 18. Epub ahead of print
[http://dx.doi.org/10.3390/ijms18102170] [PMID: 29057787]
[10]
Liu X, Nelson A, Wang X, et al. Vitamin D modulates prostaglandin E2 synthesis and degradation in human lung fibroblasts. Am J Respir Cell Mol Biol 2014; 50(1): 40-50.
[PMID: 23941558]
[11]
Lu D, Lan B, Din Z, Chen H, Chen G. A vitamin D receptor agonist converts CD4+ T cells to Foxp3+ regulatory T cells in patients with ulcerative colitis. Oncotarget 2017; 8(32): 53552-62.
[http://dx.doi.org/10.18632/oncotarget.18614] [PMID: 28881831]
[12]
Roy S, Sherman A, Monari-Sparks MJ, Schweiker O, Hunter K. Correction of low vitamin D improves fatigue: Effect of correction of low vitamin D in fatigue study (EViDiF Study). N Am J Med Sci 2014; 6(8): 396-402.
[http://dx.doi.org/10.4103/1947-2714.139291] [PMID: 25210673]
[13]
Rooney MR, Harnack L, Michos ED, Ogilvie RP, Sempos CT, Lutsey PL. Trends in use of high-dose vitamin D supplements exceeding 1000 or 4000 international units daily, 1999-2014. JAMA 2017; 317(23): 2448-50.
[http://dx.doi.org/10.1001/jama.2017.4392] [PMID: 28632857]
[14]
Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ 2021; 372(160): n160.
[http://dx.doi.org/10.1136/bmj.n160] [PMID: 33781993]
[15]
Sterne JA, Savović J, Page MJ, et al. RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ 2019; 366: l4898.
[http://dx.doi.org/10.1136/bmj.l4898] [PMID: 31462531]
[16]
National Heart, Lung, and Blood Institute. Study Quality Assessment Tools Available from: https://www. nhlbi.nih.gov/health-topics/study-quality-assessment-tools (Accessed on 6 June 2021)
[17]
Moola S, Munn Z, Tufanaru C, et al. Chapter 7 Systematic reviews of aetiology and risk Joanna Briggs Institute Reviewer’s Manual The Joanna Briggs Institute. 2017. Available from: https://reviewersmanual.joannabriggs.org
[18]
Tabra SA, Abu-Zaid MH, Hablas S. THU0471 vitamin D supplementation; is it effective in fibromyalgia patients? Ann Rheum Dis 2020; 79 (Suppl. 1): 472-3.
[http://dx.doi.org/10.1136/annrheumdis-2020-eular.487]
[19]
Abou-Raya S, Abou-Raya A, Helmii M. THU0327 efficacy of vitamin D supplementation in the treatment of fibromyalgia: Randomized controlled trial. Ann Rheum Dis 2014; 73 (Suppl. 2): 295-5.
[http://dx.doi.org/10.1136/annrheumdis-2014-eular.2767]
[20]
McGuinness LA, Higgins JPT. Risk-of-bias visualization (robvis): An R package and shiny web app for visualizing risk-of-bias assessments. Res Synth Methods 2021; 12(1): 55-61.
[http://dx.doi.org/10.1002/jrsm.1411] [PMID: 32336025]
[21]
de Carvalho JF, Lerner A. Fibromyalgia associated with Chagas’ disease treated with nutraceuticals. Clin Nutr ESPEN 2021; 42: 212-4.
[http://dx.doi.org/10.1016/j.clnesp.2021.01.037] [PMID: 33745580]
[22]
de Carvalho JF, da Rocha Araújo FA, da Mota LMA, Aires RB, de Araujo RP. Vitamin D supplementation seems to improve fibromyalgia symptoms: Preliminary results. Isr Med Assoc J 2018; 20(6): 379-81.
[PMID: 29911760]
[23]
Lozano-Plata LI, Vega-Morales D, Esquivel-Valerio JA, et al. Efficacy and safety of weekly vitamin D3 in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial. Clin Rheumatol 2021; 40(8): 3257-64. Epub ahead of print
[http://dx.doi.org/10.1007/s10067-021-05640-8] [PMID: 33570701]
[24]
Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of vitamin D therapy on quality of life in patients with fibromyalgia. Eurasian J Med 2017; 49(2): 113-7.
[http://dx.doi.org/10.5152/eurasianjmed.2017.16283] [PMID: 28638253]
[25]
Yilmaz R, Salli A, Cingoz HT, Kucuksen S, Ugurlu H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis 2016; 19(12): 1255-62.
[http://dx.doi.org/10.1111/1756-185X.12960] [PMID: 27860257]
[26]
Wepner F, Scheuer R, Schuetz-Wieser B, et al. Effects of vitamin D on patients with fibromyalgia syndrome: A randomized placebo-controlled trial. Pain 2014; 155(2): 261-8.
[http://dx.doi.org/10.1016/j.pain.2013.10.002] [PMID: 24438771]
[27]
Matthana MH. The relation between vitamin D deficiency and fibromyalgia syndrome in women. Saudi Med J 2011; 32(9): 925-9.
[PMID: 21894355]
[28]
Mirzaei A, Zabihiyeganeh M, Jahed SA, Khiabani E, Nojomi M, Ghaffari S. Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. Med J Islam Repub Iran 2018; 32(1): 29.
[http://dx.doi.org/10.14196/mjiri.32.29] [PMID: 30159280]
[29]
ALdaoseri HA, Zubairi MB, ALdaoseri HA, Zubairi MB. Vitamin D deficiency and treatment in Iraqi patients with primary fibromyalgia syndrome. Egypt Rheumatol 2020; 42(1): 47-50.
[http://dx.doi.org/10.1016/j.ejr.2019.05.002]
[30]
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M. Effectiveness of therapeutic exercise in fibromyalgia syndrome: A systematic review and meta-analysis of randomized clinical trials. BioMed Res Int 2017; 2017: 2356346.
[http://dx.doi.org/10.1155/2017/2356346] [PMID: 29291206]
[31]
Hudson JI, Arnold LM, Keck PE Jr, Auchenbach MB, Pope HG Jr. Family study of fibromyalgia and affective spectrum disorder. Biol Psychiatry 2004; 56(11): 884-91.
[http://dx.doi.org/10.1016/j.biopsych.2004.08.009] [PMID: 15576066]
[32]
Arnold LM, Hudson JI, Hess EV, et al. Family study of fibromyalgia. Arthritis Rheum 2004; 50(3): 944-52.
[http://dx.doi.org/10.1002/art.20042] [PMID: 15022338]
[33]
Bradley LA. Pathophysiology of fibromyalgia. Am J Med 2009; 122(12) (Suppl.): S22-30.
[http://dx.doi.org/10.1016/j.amjmed.2009.09.008] [PMID: 19962493]
[34]
Hsiao MY, Hung CY, Chang KV, Han DS, Wang TG. Is serum hypovitaminosis D associated with chronic widespread pain including fibromyalgia? A meta-analysis of observational studies. Pain Physician 2015; 18(5): E877-87.
[PMID: 26431141]
[35]
Okumus M, Koybası M, Tuncay F, et al. Fibromyalgia syndrome: Is it related to vitamin D deficiency in premenopausal female patients? Pain Manag Nurs 2013; 14(4): e156-63.
[http://dx.doi.org/10.1016/j.pmn.2011.09.006] [PMID: 24315268]
[36]
Mateos F, Valero C, Olmos JM, et al. Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia. Osteoporos Int 2014; 25(2): 525-33.
[http://dx.doi.org/10.1007/s00198-013-2434-2] [PMID: 24008400]
[37]
Gaikwad M, Vanlint S, Mittinity M, Moseley GL, Stocks N. Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain? A systematic review and meta-analysis. Clin Rheumatol 2017; 36(5): 1201-8.
[http://dx.doi.org/10.1007/s10067-016-3205-1] [PMID: 26861032]
[38]
Ellis SD, Kelly ST, Shurlock JH, Hepburn ALN. The role of vitamin D testing and replacement in fibromyalgia: A systematic literature review. BMC Rheumatol 2018; 2(1): 28.
[http://dx.doi.org/10.1186/s41927-018-0035-6] [PMID: 30886978]
[39]
Yong WC, Sanguankeo A, Upala S. Effect of vitamin D supplementation in chronic widespread pain: A systematic review and meta-analysis. Clin Rheumatol 2017; 36(12): 2825-33.
[http://dx.doi.org/10.1007/s10067-017-3754-y] [PMID: 28812209]
[40]
Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of vitamin D supplementation on pain: A systematic review and meta-analysis. Pain Physician 2016; 19(7): 415-27.
[PMID: 27676659]
[41]
Holick MF. Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19(2): 73-8.
[http://dx.doi.org/10.1016/j.annepidem.2007.12.001] [PMID: 18329892]
[42]
Binkley N, Krueger D, Cowgill CS, et al. Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization. J Clin Endocrinol Metab 2004; 89(7): 3152-7.
[http://dx.doi.org/10.1210/jc.2003-031979] [PMID: 15240586]
[43]
Durazo-Arvizu RA, Tian L, Brooks SPJ, et al. The Vitamin D Standardization Program (VDSP) manual for retrospective laboratory standardization of serum 25-hydroxyvitamin D data. J AOAC Int 2017; 100(5): 1234-43.
[http://dx.doi.org/10.5740/jaoacint.17-0196] [PMID: 28718397]
[44]
Turck D, Bresson JL. FSA panel on dietetic products; Nutrition and allergies (EFSA NDA Panel). Update of the tolerable upper intake level for vitamin D for infants. EFSA J 2018; 16(8): e05365.
[http://dx.doi.org/10.2903/j.efsa.2018.5365]
[45]
Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis. Am J Clin Nutr 2012; 95(6): 1357-64.
[http://dx.doi.org/10.3945/ajcn.111.031070] [PMID: 22552031]
[46]
Malihi Z, Wu Z, Stewart AW, Lawes CM, Scragg R. Hypercalcemia, hypercalciuria, and kidney stones in long-term studies of vitamin D supplementation: A systematic review and meta-analysis. Am J Clin Nutr 2016; 104(4): 1039-51.
[http://dx.doi.org/10.3945/ajcn.116.134981] [PMID: 27604776]
[47]
Kearns MD, Alvarez JA, Tangpricha V. Large, single-dose, oral vitamin D supplementation in adult populations: A systematic review. Endocr Pract 2014; 20(4): 341-51.
[http://dx.doi.org/10.4158/EP13265.RA] [PMID: 24246341]
[48]
Macfarlane GJ, Kronisch C, Dean LE, et al. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis 2017; 76(2): 318-28.
[http://dx.doi.org/10.1136/annrheumdis-2016-209724] [PMID: 27377815]
[49]
Ablin J, Fitzcharles MA, Buskila D, Shir Y, Sommer C, Häuser W. Treatment of fibromyalgia syndrome: Recommendations of recent evi-dence-based interdisciplinary guidelines with special emphasis on complementary and alternative therapies. Evid Based Complement Alternat Med 2013; 2013: 485272.
[http://dx.doi.org/10.1155/2013/485272] [PMID: 24348701]
[50]
Arranz LI, Canela MA, Rafecas M. Fibromyalgia and nutrition, what do we know? Rheumatol Int 2010; 30(11): 1417-27.
[http://dx.doi.org/10.1007/s00296-010-1443-0] [PMID: 20358204]
[51]
Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B. Nutritional interventions in the management of fibromyalgia syndrome. Nutrients 2020; 12(9): 20. Epub ahead of print
[http://dx.doi.org/10.3390/nu12092525] [PMID: 32825400]
[52]
Senna MK, Sallam RA-ER, Ashour HS, Elarman M. Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: A randomized controlled trial. Clin Rheumatol 2012; 31(11): 1591-7.
[http://dx.doi.org/10.1007/s10067-012-2053-x] [PMID: 22948223]
[53]
Slim M, Calandre EP, Garcia-Leiva JM, et al. The effects of a gluten-free diet versus a hypocaloric diet among patients with fibromyalgia experiencing gluten sensitivity-like symptoms: A pilot, open-label randomized clinical trial. J Clin Gastroenterol 2017; 51(6): 500-7.
[http://dx.doi.org/10.1097/MCG.0000000000000651] [PMID: 27548732]
[54]
Marum AP, Moreira C, Tomas-Carus P, Saraiva F, Guerreiro CS. A low Fermentable Oligo-Di-Mono-saccharides And Polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits. Nutr Hosp 2017; 34(3): 667-74.
[http://dx.doi.org/10.20960/nh.703] [PMID: 28627205]
[55]
Holton KF, Taren DL, Thomson CA, Bennett RM, Jones KD. The effect of dietary glutamate on fibromyalgia and irritable bowel symptoms. Clin Exp Rheumatol 2012; 30(6) (Suppl. 74): 10-7.
[PMID: 22766026]

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