Perspectives and Prospects on mRNA Vaccine Development for COVID-19

Title:Perspectives and Prospects on mRNA Vaccine Development for COVID-19

Volume: 29 Issue: 23

Author(s): Lihui Jin, Zhenyuan Han, Pengjun Zhao*Kun Sun*

Affiliation:

• Pediatric Heart Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China

• Pediatric Heart Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China

Keywords: Coronavirus disease 2019 (COVID-19), SARS-CoV-2, mRNA vaccine, chemical modifications, mRNA- 1273, BNT162b2.

Abstract:

Background: The current coronavirus disease 2019 (COVID-19) pandemic, since first reported in Wuhan, has inspired worldwide efforts to develop effective COVID-19 vaccination strategies. mRNA vaccines encoding COVID-19 antigens have emerged prominantlyin this global race due to their high effectiveness and simple manufacturing process. Notably, two COVID-19 mRNA vaccines, mRNA-1273 and BNT162b2, have survived in clinical trials and been authorized for emergency use across variouscountries.

Summary: Recent advances on mRNA vaccine development for COVID-19 are discussed in this perspective, including sequence design, chemical modification, manufacturing process, and in vivo delivery. Phase I to IV clinical trials of mRNA-1273 and BNT162b2 are then summarized, respectively.

Conclusion: Using mRNA vaccines is a promising strategy to achieve mass vaccination in the COVID-19 pandemic. We hope that future studies of mRNA vaccine technology will overcome existing limitations and help people cope with COVID-19.

Cite this article as:

Jin Lihui, Han Zhenyuan, Zhao Pengjun*, Sun Kun*, Perspectives and Prospects on mRNA Vaccine Development for COVID-19, Current Medicinal Chemistry 2022; 29 (23) . https://dx.doi.org/10.2174/0929867329666220216110931