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ISSN (Online): 1875-5607

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Review Article

Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer

Author(s): Jahara Shaikh, Kavitkumar Patel* and Tabassum Khan

Volume 22, Issue 8, 2022

Published on: 13 January, 2022

Page: [1197 - 1215] Pages: 19

DOI: 10.2174/1389557521666211027104957

Price: $65

Abstract

The transformation of a normal cell into a tumor cell is one of the initial steps in cell cycle deregulation. The cell cycle is regulated by cyclin-dependent kinases (CDKs) that belong to the protein kinase family. CDK2 is an enchanting target for specific genotype tumors since cyclin E is selective for CDK2 and the deregulation of specific cancer types. Thus, CDKs inhibitor, specifically CDK2/cyclin A-E, has the potential to be a valid cancer target as per the currently undergoing clinical trials. Most of the pyrazole scaffolds have shown selectivity and potency for CDK2 inhibitors. This review aims at examining pyrazole and pyrazole fused with other heterocyclic rings for antiproliferative activity. Based on the in vitro and molecular docking studies, the most potent analogues for CDK2 inhibition are exhibited by IC50 value. Moreover, the review emphasizes the various lead analogs of pyrazole hybrids which can be very potent and selective for anti-cancer drugs.

Keywords: Cyclin-Dependent Kinase (CDK) inhibitor, cell cycle, CDK2 inhibitors, pyrazole derivatives, SAR, anti-cancer agents.

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