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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Systematic Review Article

Chlamydia pneumoniae and Mycoplasma pneumoniae as Two Emerging Risk Factors in Atherosclerosis: Meta-Analysis Study and Systematic Review

Author(s): Mahsa Jalili , Hassan Nourmohammadi and Kourosh Sayehmiri *

Volume 22, Issue 1, 2022

Published on: 21 September, 2021

Article ID: e210921196697 Pages: 10

DOI: 10.2174/1871526521666210921121423

Price: $65

Abstract

Background: Previous studies suggested an association between Chlamydia pneumoniae and Mycoplasma pneumonia with atherosclerosis, separately. Until now, according to inconsistent information, the relationship between C.pneumoniae and M.pneumoniae with atherosclerosis is controversial.

Objective: The aim of this study is to investigate the association between C.pneumoniae and M.pneumoniae as two separate risk factors with atherosclerosis through systematic review and metaanalysis study.

Methods: We searched databases, such as Pubmed, SID, Magiran, Google scholar and Iranmedex, using the following keywords in English and Persian language: C. pneumoniae, M. pneumoniae, and atherosclerosis. Data were analyzed with meta-analysis and a random effect model. Also, in this study, heterogeneity of articles was estimated by using the I2 index. Finally, the data were analyzed with STAT (version 11.2).

Results: Among thirty-eight articles for C. pneumoniae and five articles for M. pneumoniae individually reviewed that included 2980 samples for M. pneumoniae and 23298 samples for C. pneumoniae, the result demonstrated that the association between M. pneumoniae and C. pneumoniae with atherosclerosis is significant with OR (odds ratio) = 1.58 (95% Confidence Interval (CI): 1.00 to 2.50), OR (odds ratio) = 2.25 (95% Confidence Interval (CI): 1.91 to 2.64), respectively.

Conclusion: This systematic review study provides strong evidence for the role of persistent bacterial infections, such as M. pneumoniae and C. pneumoniae, in potential atherosclerosis. Thus, a novel way should be employed for the complete management of bacterial infection.

Keywords: Mycoplasma pneumoniae, Chlamydia pneumoniae, atherosclerosis, odds ratio, bacterial infections, inflammatory disease.

Graphical Abstract
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