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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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Review Article

Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics

Author(s): Chandrabose Selvaraj*, Dhurvas Chandrasekaran Dinesh, Petra Krafcikova, Evzen Boura, Murali Aarthy, Muthuraja Arun Pravin and Sanjeev Kumar Singh*

Volume 15, Issue 2, 2022

Published on: 20 December, 2021

Article ID: e060921196186 Pages: 16

DOI: 10.2174/1874467214666210906125959

Price: $65

Abstract

The pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV- 2), is responsible for multiple worldwide lockdowns, an economic crisis, and a substantial increase in hospitalizations for viral pneumonia along with respiratory failure and multiorgan dysfunctions. Recently, the first few vaccines were approved by World Health Organization (WHO) and can eventually save millions of lives. Even though, few drugs are used in emergency like Remdesivir and several other repurposed drugs, still there is no approved drug for COVID-19. The coronaviral encoded proteins involved in host-cell entry, replication, and host-cell invading mechanism are potential therapeutic targets. This perspective review provides the molecular overview of SARS-CoV-2 life cycle for summarizing potential drug targets, structural insights, active site contour map analyses of those selected SARS-CoV-2 protein targets for drug discovery, immunology, and pathogenesis.

Keywords: SARS-CoV-2, COVID-19, repurposing, FDA, drug targets, antivirals, active site, contour maps, medicinal plants, phytochemicals, TCM, natural products.

Graphical Abstract

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