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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Research Article

Study on the Effects of Kuanxiong Aerosol on the Isolated Artery and Rabbits Acute Myocardial Ischemia Model

Author(s): Xia Liu, Feihua Huang, Xiao Lu, Yuji Wang, Tingting Cai, Aiping Peng and Wanping Zhu*

Volume 25, Issue 9, 2022

Published on: 12 January, 2022

Page: [1534 - 1544] Pages: 11

DOI: 10.2174/1386207324666210811142312

Price: $65

Abstract

Background: Kuan Xiong aerosol (KXA) is a Chinese herbal compound used to regulate qi-flowing to relieve pain and improve angina. However, only a few pharmacological studies on this traditional Chinese medicine preparation have been reported to confirm these activities.

Objectives: This article aims to observe the effect of resisting acute myocardial ischemia (AMI) in vivo and dilating vessel in vitro of KXA.

Methods: The AMI model involves intravenously injecting the pituitary (2 U.kg-1) into the ear of rabbits. Electrocardiograph (ECG) T waves were then recorded after administration, and the falling range was calculated. Following this, the level of serum Cardiac troponin T (cTn-T) and the histopathology of the cardiac muscle tissue were evaluated. In vitro, the effect of KXA on vasodilation of isolated aortic rings that had been pre-contracted with KCl (30 mM) was observed.

Results: It was found that KXA reduced ECG ST-T waves and serum cTn-T in the rabbit AMI model, protecting myocardial tissue from fracturing and loss of myocardial fibers and inhibiting inflammatory cell infiltration, cavitation degeneration, and karyopyknosis of the myocardial matrix. Furthermore, the administration of 0.215, 1.075, and 2.150 mg.mL-1 of KXA resulted in significant relaxation of the aortic rings at a rate of 69.63 %, 90.14 %, and 118.72 % (p < 0.01) in the untreated ones, and a second shrinkage ratio of 20.17 %, 4.29 %, and 4.54 % (p < 0.01) in the untreated ones, respectively.

Conclusion: These results suggest that KXA protects against AMI, contributes to the dilation of blood vessels, and has long-acting effectiveness.

Keywords: Kuan xiong aerosol, volatile oils, acute myocardial ischemia, myocardial injury, vasodilatation, cardiac troponin T.

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[1]
Chong, C.R.; Ong, G.J.; Horowitz, J.D. Emerging drugs for the treatment of angina pectoris. Expert Opin. Emerg. Drugs, 2016, 21(4), 365-376.
[http://dx.doi.org/10.1080/14728214.2016.1241231] [PMID: 27686005]
[2]
Santucci; Andrea, R.; Clara, C.; Claudio, Treatment of stable ischaemic heart disease: the old and the new. Eur. Heart J. Suppl., 2020, 22, E54-E59.
[http://dx.doi.org/10.1093/eurheartj/suaa060]
[3]
Pan, X.; Bao, H.; Si, Y.; Xu, C.; Chen, H.; Gao, X.; Xie, X.; Xu, Y.; Sun, F.; Zeng, L. Spinal cord stimulation for refractory angina pectoris: A systematic review and meta-analysis. Clin. J. Pain, 2017, 33(6), 543-551.
[http://dx.doi.org/10.1097/AJP.0000000000000435] [PMID: 27875377]
[4]
Makowski, M.; Makowska, J.S. Zielińska, M. Refractory angina-unsolved problem. Cardiol. Clin., 2020, 38(4), 629-637.
[http://dx.doi.org/10.1016/j.ccl.2020.07.009] [PMID: 33036723]
[5]
Montalescot, G.; Sechtem, U.; Achenbach, S.; Andreotti, F.; Arden, C.; Budaj, A.; Bugiardini, R.; Crea, F.; Cuisset, T.; Di Mario, C.; Fer-reira, J.R.; Gersh, B.J.; Gitt, A.K.; Hulot, J.S.; Marx, N.; Opie, L.H.; Pfisterer, M.; Prescott, E.; Ruschitzka, F.; Sabaté, M.; Senior, R.; Tag-gart, D.P.; van der Wall, E.E.; Vrints, C.J.; Zamorano, J.L.; Achenbach, S.; Baumgartner, H.; Bax, J.J.; Bueno, H.; Dean, V.; Deaton, C.; Erol, C.; Fagard, R.; Ferrari, R.; Hasdai, D.; Hoes, A.W.; Kirchhof, P.; Knuuti, J.; Kolh, P.; Lancellotti, P.; Linhart, A.; Nihoyannopoulos, P.; Piepoli, M.F.; Ponikowski, P.; Sirnes, P.A.; Tamargo, J.L.; Tendera, M.; Torbicki, A.; Wijns, W.; Windecker, S.; Knuuti, J.; Valgimigli, M.; Bueno, H.; Claeys, M.J.; Donner-Banzhoff, N.; Erol, C.; Frank, H.; Funck-Brentano, C.; Gaemperli, O.; Gonzalez-Juanatey, J.R.; Hami-los, M.; Hasdai, D.; Husted, S.; James, S.K.; Kervinen, K.; Kolh, P.; Kristensen, S.D.; Lancellotti, P.; Maggioni, A.P.; Piepoli, M.F.; Pries, A.R.; Romeo, F.; Rydén, L.; Simoons, M.L.; Sirnes, P.A.; Steg, P.G.; Timmis, A.; Wijns, W.; Windecker, S.; Yildirir, A.; Zamorano, J.L. 2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European society of cardiology. Eur. Heart J., 2013, 34(38), 2949-3003. [published correction appears in Eur Heart J. 2014 Sep 1;35(33):2260-1].
[http://dx.doi.org/10.1093/eurheartj/eht296] [PMID: 23996286]
[6]
Kloner, R.A.; Chaitman, B. Angina and its management. J. Cardiovasc. Pharmacol. Ther., 2017, 22(3), 199-209.
[http://dx.doi.org/10.1177/1074248416679733] [PMID: 28196437]
[7]
Palaniappan, M.; Selvarajan, S.; George, M.; Subramaniyan, G.; Dkhar, S.A.; Pillai, A.A.; Jayaraman, B.; Chandrasekaran, A. Pattern of adverse drug reactions reported with cardiovascular drugs in a tertiary care teaching hospital. J. Clin. Diagn. Res., 2015, 9(11), FC01-FC04.
[http://dx.doi.org/10.7860/JCDR/2015/13810.6704] [PMID: 26675485]
[8]
Shanmugam, H.; Panneerselvam, N.; Lawrence, A.A. Adverse drug reactions of cardiovascular drugs in intensive cardiac care unit in a tertiary care hospital: A prospective study. Biomed. Pharmacol. J., 2019, 12(3), 1079-1083.
[http://dx.doi.org/10.13005/bpj/1737]
[9]
Guo, S.K.; Chen, K.J.; Weng, W.L.; Zhang, W.Q.; Yu, Y.Q. Immediate effect of Kuan-xiong aerosol in the treatment of anginal attacks. Planta Med., 1983, 47(2), 116.
[http://dx.doi.org/10.1055/s-2007-969967] [PMID: 6844452]
[10]
Lu, Y.; Yang, M.; Peng, M.; Xie, L.; Shen, A.; Lin, S.; Huang, B.; Chu, J.; Peng, J. Kuanxiong aerosol inhibits apoptosis and attenuates isoproterenol-induced myocardial injury through the mitogen-activated protein kinase pathway. J. Ethnopharmacol., 2021, 269, 113757.
[http://dx.doi.org/10.1016/j.jep.2020.113757] [PMID: 33359915]
[11]
Zhang, Y.; Wu, J.; Guo, S.; Lin, W.; Zhang, B.; Chen, X.; Mo, H.; Zhan, T. The clinical efficacy and safety of the Chinese herbal medicine Astragalus (Huangqi) preparation for the treatment of acute myocardial infarction: A systematic review of randomized controlled trials. Medicine (Baltimore), 2019, 98(16), e15256.
[http://dx.doi.org/10.1097/MD.0000000000015256] [PMID: 31008964]
[12]
Yang, Q.N.; Bai, R.N.; Dong, G.J.; Ge, C.J.; Zhou, J.M.; Huang, L.; He, Y.; Wang, J.; Ren, A.H.; Huang, Z.Q.; Zhu, G.L.; Lu, S.; Xiong, S.Q.; Xian, S.X.; Zhu, Z.J.; Shi, D.Z.; Lu, S.Z.; Li, L.Z.; Chen, K.J. Effect of Kuanxiong aerosol on patients with angina pectoris: A non-inferiority multi-center randomized controlled trial. Chin. J. Integr. Med., 2018, 24(5), 336-342.
[http://dx.doi.org/10.1007/s11655-018-2833-5] [PMID: 29435729]
[13]
Zhuang, J.; Dai, X.; Zhang, H.; Chen, Y.; Cai, H.; Jin, Z.; Zhong, L.; Chen, B. A meta-analysis for kuanxiong aerosol on the treatment of angina pectoris. Am. J. Emerg. Med., 2020, 38(6), 1218-1225.
[http://dx.doi.org/10.1016/j.ajem.2020.01.045] [PMID: 32107129]
[14]
Evangelista, V.; Dell’Elba, G.; Celardo, A.; Manarini, S.; Cerletti, C. TxA2-mediated myocardial ischemia as a consequence of an acute lung inflammatory reaction in the rabbit. J. Thromb. Haemost., 2003, 1(2), 314-319.
[http://dx.doi.org/10.1046/j.1538-7836.2003.00067.x] [PMID: 12871506]
[15]
Li, X.L.; Chen, L.Y.; Guan, Z.Y.; Luo, Y.; Cui, Y.R.; Liu, R.H.; Shao, F.; Wang, D.Q. Effect of neoflavonoid latifolin isolated from Dal-bergia odorifera on acute myocardial ischemia in rats and its mechanism of Nrf2 signaling pathway. Zhongguo Zhongyao Zazhi, 2017, 42(20), 3974-3982.
[http://dx.doi.org/10.19540/j.cnki.cjcmm.20170907.009] [PMID: 29243436]
[16]
Wang, Y.; Sheng, Z.; Li, J.; Tan, Y.; Zhou, P.; Liu, C.; Zhao, X.; Zhou, J.; Chen, R.; Song, L.; Zhao, H.; Yan, H. Association between pre-infarction angina and culprit-lesion morphology in patients with ST-segment elevation myocardial infarction: an optical coherence tomog-raphy study. Eur. Heart J., 2020, 41(S2), 946-2460.
[http://dx.doi.org/10.1093/ehjci/ehaa946.2460]
[17]
de França-Neto, A.; Cardoso-Teixeira, A.C.; Medeiros, T.C. Quinto-Farias, Mdo.S.; Sampaio, C.M.; Coelho-de-Souza, A.N.; Lahlou, S.; Leal-Cardoso, J.H. Essential oil of Croton argyrophylloides: toxicological aspects and vasorelaxant activity in rats. Nat. Prod. Commun., 2012, 7(10), 1397-1400.
[http://dx.doi.org/10.1177/1934578X1200701040] [PMID: 23157021]
[18]
Qu, J.; Liu, F.; Zhang, X.; Wang, J.; Oroxylin, A. Oroxylin A reduces vasoconstriction in rat aortic rings through promoting NO production and NOS protein expression via estrogen receptor signal pathway. Evid. Based Complement. Alternat. Med., 2020, 2020, 9257950.
[http://dx.doi.org/10.1155/2020/9257950] [PMID: 32082399]
[19]
Sacks, D.; Baxter, B.; Campbell, B.C.V.; Carpenter, J.S.; Cognard, C.; Dippel, D.; Eesa, M.; Fischer, U.; Hausegger, K.; Hirsch, J.A.; Hussain, M.S.; Jansen, O.; Jayaraman, M.V.; Khalessi, A.A.; Kluck, B.W.; Lavine, S.; Meyers, P.M.; Ramee, S.; Rüfenacht, D.A.; Schirm-er, C.M.; Vorwerk, D. Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute is-chemic stroke. AJNR Am. J. Neuroradiol., 2018, 39(6), E61-E76.
[http://dx.doi.org/10.3174/ajnr.A5638] [PMID: 29773566]
[20]
Gómez, M.A.; Migues, I.; Caggiania, M.; Arias, X.; Laprovitera, M.; Blanco, F.; Cesio, M.V.; Migliaro, E.R.; Heinzen, H. Vasorelaxant effect of a baccharis trimera infusion on precontracted rat aortic rings. Nat. Prod. Commun., 2016, 11(3), 283-286.
[http://dx.doi.org/10.1177/1934578X1601100304] [PMID: 27169175]
[21]
Huang, Y.; Sun, M.; Cui, H.; Kong, L.; Zhai, H.; Wang, Y.; Lü, C.; Fan, D. Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats. J. Tradit. Chin. Med., 2019, 39(4), 492-501.
[PMID: 32186096]
[22]
Gorzalczany, S.; Moscatelli, V.; Ferraro, G. Artemisia copa aqueous extract as vasorelaxant and hypotensive agent. J. Ethnopharmacol., 2013, 148(1), 56-61.
[http://dx.doi.org/10.1016/j.jep.2013.03.061] [PMID: 23588093]
[23]
Huo, L.; Zhang, J.; Qu, Z.; Chen, H.; Li, Y.; Gao, W. Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta. J. Ethnopharmacol., 2015, 173, 352-360.
[http://dx.doi.org/10.1016/j.jep.2015.07.048] [PMID: 26239154]
[24]
Knox, M.; Vinet, R.; Fuentes, L.; Morales, B.; Martínez, J.L. A review of endothelium-dependent and -independent vasodilation induced by phytochemicals in isolated rat aorta. Animals (Basel), 2019, 9(9), 623.
[http://dx.doi.org/10.3390/ani9090623] [PMID: 31470540]
[25]
Wang, X.; Zhang, L.; Gao, C.; Wu, S.; Zhu, J. ST-segment elevation and the Tpeak-Tend/QT ratio predict the occurrence of malignant ar-rhythmia events in patients with vasospastic angina. J. Electrocardiol., 2019, 53, 52-56.
[http://dx.doi.org/10.1016/j.jelectrocard.2019.01.001] [PMID: 30616002]
[26]
Lin, S.; Chu, J.; Zhang, L.; Chen, D.; Xiao, F.; Chen, H.; Lin, J.; Chen, Y.; Zhu, Y.; Peng, J. Protective effects of Shexiang Tongxin Drop-ping Pill on pituitrin induced acute myocardial ischemia in rats. Mol. Med. Rep., 2017, 16(3), 3125-3132.
[http://dx.doi.org/10.3892/mmr.2017.6963] [PMID: 28714023]
[27]
Black, J.W. [Electrocardiographic changes produced in rabbits by vasopressin (pitressin) and their alteration by prolonged treatment with a commercial heart extract]. J. Pharm. Pharmacol., 1960, 12, 87-94.
[http://dx.doi.org/10.1111/j.2042-7158.1960.tb12635.x] [PMID: 13848094]
[28]
Li, F.; Fan, X.X.; Chu, C.; Zhang, Y.; Kou, J.P.; Yu, B.Y. A strategy for optimizing the combination of active components based on Chi-nese medicinal formula Sheng-Mai-San for myocardial ischemia. Cell. Physiol. Biochem., 2018, 45(4), 1455-1471.
[http://dx.doi.org/10.1159/000487572] [PMID: 29466787]
[29]
Cao, Z.; Zhao, M.; Xu, C.; Zhang, T.; Jia, Y.; Wang, T.; Zhu, B. Diagnostic roles of postmortem cTn I and cTn T in cardiac death with special regard to myocardial infarction: A systematic literature review and meta-analysis. Int. J. Mol. Sci., 2019, 20(13), 3351.
[http://dx.doi.org/10.3390/ijms20133351] [PMID: 31288395]
[30]
Telia, A.A.; Telia, A.Z.; Machavariani, K.; Telia, Z. Sublingual immunotherapy for allergic asthma and rhinitis. Georgian Med. News, 2018, (276), 123-130.
[PMID: 29697395]
[31]
Yamamoto, K.; Kobayashi, M. Opposite roles in short-term plasticity for N-type and P/Q-type voltage-dependent calcium channels in GABAergic neuronal connections in the rat cerebral cortex. J. Neurosci., 2018, 38(46), 9814-9828.
[http://dx.doi.org/10.1523/JNEUROSCI.0337-18.2018] [PMID: 30249804]
[32]
Tykocki, N.R.; Boerman, E.M.; Jackson, W.F. Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arte-rioles. Compr. Physiol., 2017, 7(2), 485-581.
[http://dx.doi.org/10.1002/cphy.c160011] [PMID: 28333380]
[33]
Contini, D.; Holstein, G.R.; Art, J.J. Synaptic cleft microenvironment influences potassium permeation and synaptic transmission in hair cells surrounded by calyx afferents in the turtle. J. Physiol., 2020, 598(4), 853-889.
[http://dx.doi.org/10.1113/JP278680] [PMID: 31623011]

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