Abstract
It is established that the gut microbiota has a significant influence on Alzheimer’s disease. In turn, both the disease and the microbiota are affected by biological variables associated with modern lifestyles. Examination of the potential interrelationship among these three factors and on the role played by lifestyles in gut dysbiosis-induced pathologies of Alzheimer’s disease are limited. Deciphering these connections will provide insights into the pathogenesis and therapeutic strategies for Alzheimer’s disease. Specifically, based on this trilateral relationship, various nonpharmacological interventive strategies targeting the gut microbiota can be developed. This review fills this gap by presenting the latest evidence for the modulative role of modern lifestyle on the gut microbiota and its relevance to Alzheimer’s disease, with a discussion on the limitations of current research and future directions.
Keywords: Gut microbiota, Alzheimer's disease, modern lifestyle, dietary pattern, exercise, mental stress.
Current Aging Science
Title:Gut Microbiota as a Link between Modern Lifestyle and Alzheimer’s Disease
Volume: 14 Issue: 3
Author(s): Yi Wang*Gary Dykes
Affiliation:
- School of Agriculture and Food Sciences, University of Queensland, Keyhole Road, St Lucia, Queensland 4067,Australia
Keywords: Gut microbiota, Alzheimer's disease, modern lifestyle, dietary pattern, exercise, mental stress.
Abstract: It is established that the gut microbiota has a significant influence on Alzheimer’s disease. In turn, both the disease and the microbiota are affected by biological variables associated with modern lifestyles. Examination of the potential interrelationship among these three factors and on the role played by lifestyles in gut dysbiosis-induced pathologies of Alzheimer’s disease are limited. Deciphering these connections will provide insights into the pathogenesis and therapeutic strategies for Alzheimer’s disease. Specifically, based on this trilateral relationship, various nonpharmacological interventive strategies targeting the gut microbiota can be developed. This review fills this gap by presenting the latest evidence for the modulative role of modern lifestyle on the gut microbiota and its relevance to Alzheimer’s disease, with a discussion on the limitations of current research and future directions.
Export Options
About this article
Cite this article as:
Wang Yi *, Dykes Gary , Gut Microbiota as a Link between Modern Lifestyle and Alzheimer’s Disease, Current Aging Science 2021; 14 (3) . https://dx.doi.org/10.2174/1874609814666210609100048
DOI https://dx.doi.org/10.2174/1874609814666210609100048 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Expression and Functions of Vasoactive Substances Regulated by Hypoxia-Inducible Factor-1 in Chronic Hypoxemia
Cardiovascular & Hematological Agents in Medicinal Chemistry Sclerosing Polidocanol Injections of Small Vessels to Treat the Chronic Painful Tendon
Cardiovascular & Hematological Agents in Medicinal Chemistry Cytomegalovirus Infection in Pediatric Immunocompromised Hosts
Infectious Disorders - Drug Targets Herbal Highs: Review on Psychoactive Effects and Neuropharmacology
Current Neuropharmacology Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates
Current Drug Targets Graphical Abstracts
Letters in Drug Design & Discovery Pharmacokinetics and Metabolic Drug Interactions
Current Clinical Pharmacology Diabetes Mellitus and SARS-CoV-2 Infection: Pathophysiologic Mechanisms and Implications in Management
Current Diabetes Reviews Novel Biological Therapies in Severe Asthma: Targeting the Right Trait
Current Medicinal Chemistry Impact on Pharmaceutical Industry due to Sudden Pandemic Attack (COVID-19)
Coronaviruses Biological Characterization and Preliminary Crystallization: A Step Towards the Use of Novel Allium sativum Protease Inhibitor as a Potential Therapeutic Drug
Current Enzyme Inhibition Cysteinet Dysregulation in Muscular Dystrophies: A Pathogenic Network Susceptible to Therapy
Current Medicinal Chemistry Plasticity of T Cell Differentiation and Cytokine Signature: A Double-Edged Sword for Immune Responses
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Evidence on the Protective Role of High-Density Lipoprotein (HDL) in HIV-Infected Individuals
Current Vascular Pharmacology Saquinavir/Ritonavir Monotherapy as a New Nucleoside-Sparing Maintenance Strategy in Long-Term Virologically Suppressed HIVInfected Patients
Current HIV Research Polydopamine Integrated Nanomaterials and Their Biomedical Applications
Current Pharmaceutical Design Improving Safety of Gene Therapy
Current Drug Safety Cardiovascular Biology of Interleukin-6
Current Pharmaceutical Design A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking
Current Drug Abuse Reviews The Dynamics of the Hypothalamic-Pituitary-Ovarian Axis, ReproductivePerformance and Sexuality Following Bariatric Surgery
Current Women`s Health Reviews