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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Research Article

Mean Platelet Volume and Platelet Distribution Width Correlate with Microvascular Complications in Egyptian People with Type 2 Diabetes Mellitus

Author(s): Abd El-Ghany MI*, Nahed Abdallah and Waleed Eldars

Volume 17, Issue 8, 2021

Published on: 05 July, 2021

Article ID: e080621193947 Pages: 8

DOI: 10.2174/1573399817666210608121024

Abstract

Background: Type 2 diabetes is a part of metabolic syndrome associated with a higher risk of vascular complications. Diabetes is characterized by changes in platelet morphology, function, and platelet hyperactivity so, it's considered a prothrombotic condition. Morbidity and mortality in people with type 2 diabetes-related to micro and macrovascular complications. Novel biomarkers are needed to identify and treat people at higher risk.

Objective: The main objective of this controlled cross-sectional study was to evaluate Platelet volume indices (PVI) in subjects with type 2 diabetes with and without complications in comparison to subjects without diabetes.

Methods: Hundred and thirty-five subjects aged from 35 to 60 years were subdivided into 3 groups. Group A includes 55 subjects with type 2 diabetes with complications. Group B includes 45 subjects with type 2 diabetes without complications. Group C includes 35 normal healthy subjects. Detailed clinical history was taken. Also, PVI, fasting blood glucose (FBG), hemoglobin A1c, and creatinine were obtained.

Results: Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet large cell ratio (P-LCR) were significantly higher among subjects with retinopathy, nephropathy, and neuropathy than other subjects with diabetes who didn't develop complications (P<0.001). At cutoff value > 11.9 fL, MPV have diagnostic sensitivity 80% and specificity 97.8%. Whereas PDW >16.9fL has a sensitivity of 74.5% and specificity of 100% for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy).

Conclusion: MPV and PDW may be considered as possible biomarkers for the early detection of diabetic microvascular complications.

Keywords: Diabetes, platelet indices, mean platelet volume, platelet distribution width, platelet large cell ratio, microvascular complications.

[1]
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37(Suppl. 1): S81-90.
[http://dx.doi.org/10.2337/dc14-S081] [PMID: 24357215]
[2]
Colwell JA, Nesto RW. The platelet in diabetes: Focus on prevention of ischemic events. Diabetes Care 2003; 26(7): 2181-8.
[http://dx.doi.org/10.2337/diacare.26.7.2181] [PMID: 12832332]
[3]
Marshall SM, Barth JH. Standardization of HbA1c measurements a consensus statement. Diabet Med 2000; 17(1): 5-6.
[http://dx.doi.org/10.1046/j.1464-5491.2000.00228.x] [PMID: 10691152]
[4]
Ferroni P, Basili S, Falco A, Davì G. Platelet activation in type 2 diabetes mellitus. J Thromb Haemost 2004; 2(8): 1282-91.
[http://dx.doi.org/10.1111/j.1538-7836.2004.00836.x] [PMID: 15304032]
[5]
Endler G, Klimesch A, Sunder-Plassmann H, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002; 117(2): 399-404.
[http://dx.doi.org/10.1046/j.1365-2141.2002.03441.x] [PMID: 11972524]
[6]
Barutta F, Bruno G, Matullo G, et al. MicroRNA-126 and micro-/macrovascular complications of type 1 diabetes in the EURODIAB prospective complications study. Acta Diabetol 2017; 54(2): 133-9.
[http://dx.doi.org/10.1007/s00592-016-0915-4] [PMID: 27696070]
[7]
Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A, Ghirlanda G. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: A meta- analysis. Diabetes Metab Res Rev 2015; 31(4): 402-10.
[http://dx.doi.org/10.1002/dmrr.2625] [PMID: 25421610]
[8]
Mitchell RN. Hemodynamic disorders, thromboembolic disease and shock. Robbins and Cotran pathologic basis of disease. 8th ed. New Delhi: Elsevier 2010; pp. 111-34.
[http://dx.doi.org/10.1016/B978-1-4377-0792-2.50009-2]
[9]
Kakouros N, Rade JJ, Kourliouros A, Resar JR. Platelet function in patients with diabetes mellitus: From a theoretical to a practical perspective. Int J Endocrinol 2011; 2011: 742719.
[http://dx.doi.org/10.1155/2011/742719] [PMID: 21869886]
[10]
Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14(1): 28-32.
[PMID: 20411056]
[11]
Pomero F, Di Minno MN, Fenoglio L, Gianni M, Ageno W, Dentali F. Is diabetes a hypercoagulable state? A critical appraisal. Acta Diabetol 2015; 52(6): 1007-16.
[http://dx.doi.org/10.1007/s00592-015-0746-8] [PMID: 25850539]
[12]
Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J Thromb Haemost 2010; 8(1): 148-56.
[http://dx.doi.org/10.1111/j.1538-7836.2009.03584.x] [PMID: 19691485]
[13]
Martyn CN, Matthews DM, Popp-Snijders C, Tucker J, Ewing DJ, Clarke BF. Effects of sorbinil treatment on erythrocytes and platelets of persons with diabetes. Diabetes Care 1986; 9(1): 36-9.
[http://dx.doi.org/10.2337/diacare.9.1.36] [PMID: 3948646]
[14]
Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets 2006; 17(1): 67-9.
[http://dx.doi.org/10.1080/09537100500220729] [PMID: 16308190]
[15]
Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications 2009; 23(2): 89-94.
[http://dx.doi.org/10.1016/j.jdiacomp.2008.01.006] [PMID: 18358749]
[16]
Shah B, Sha D, Xie D, Mohler ER III, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: The National Health And Nutrition Examination Survey, 1999-2004. Diabetes Care 2012; 35(5): 1074-8.
[http://dx.doi.org/10.2337/dc11-1724] [PMID: 22410814]
[17]
Ünübol M, Ayhan M, Güney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets 2012; 23(6): 475-80.
[http://dx.doi.org/10.3109/09537104.2011.634934] [PMID: 22122310]
[18]
Bavbek N, Kargili A, Kaftan O, Karakurt F, Kosar A, Akcay A. Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: Are they markers of vascular disease and diabetic nephropathy? Clin Appl Thromb Hemost 2007; 13(4): 391-7.
[http://dx.doi.org/10.1177/1076029607303615] [PMID: 17911190]
[19]
Dindar S, Cinemre H, Sengul E, Annakkaya AN. Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus. West Indian Med J 2013; 62(6): 519-23.
[http://dx.doi.org/10.7727/wimj.2012.284] [PMID: 24756738]
[20]
Ates O, Kiki I, Bilen H, Keles M, Kocer I, Kulacoglu DN, et al. Association of mean platelet volume with the degree of retinopathy in patients with diabetes mellitus. Eur J Gen Med 2009; 6: 99-102.
[21]
Buch A, Kaur S, Nair R, Jain A. Platelet volume indices as predictive biomarkers for diabetic complications in Type 2 diabetic patients. J Lab Physicians 2017; 9(2): 84-8.
[http://dx.doi.org/10.4103/0974-2727.199625] [PMID: 28367021]
[22]
Mertoglu C, Gunay M. Neutrophil-Lymphocyte ratio and Platelet- Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus. Diabetes Metab Syndr 2017; 11(Suppl. 1): S127-31.
[http://dx.doi.org/10.1016/j.dsx.2016.12.021] [PMID: 28017281]

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