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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Usefulness of Honey as an Adjunct in the Radiation Treatment for Head and Neck Cancer: Emphasis on Pharmacological and Mechanism/s of Actions

Author(s): Manjeshwar S. Baliga*, Suresh Rao, Sanath K. Hegde, Pratima Rao, Paul Simon, Thomas George, Ponemone Venkatesh, Manjeshwar P. Baliga-Rao and Karadka R. Thilakchand

Volume 22, Issue 1, 2022

Published on: 26 January, 2021

Page: [20 - 29] Pages: 10

DOI: 10.2174/1871520621666210126094509

Price: $65

Abstract

Background: In the treatment of head and neck cancer (HNC), ionizing radiation is an important modality in achieving curative objectives. However, the effective use of radiation is compromised by the side effects resulting from the damage to the adjacent normal tissue. Preclinical studies carried out in the recent past have shown that the age-old dietary agent honey, which also possesses myriad medicinal use, is beneficial for mitigating diverse radiation-induced side effects like mucositis, xerostomia, fatigue, weight loss and promoting healing of refractory wounds.

Objective: The objective of this memoir is to review the beneficial effects of honey in mitigating radiation-induced side effects in HNC and to emphasize on the underlying mechanisms of action for inducing the beneficial effects.

Methods: Two authors searched Google Scholar, PubMed, Embase, and the Cochrane Library for publications up to December 2019 to assess the capability of honey for reducing the severity of radiation-induced ill effects in the treatment of HNC. Subsequently, the adjunct pharmacological effects and mechanism/s responsible were also searched for and appropriately used to substantiate the underlying mechanism/s of action for the beneficial effects.

Results: The existing data is suggestive that honey is beneficial in mitigating the radiation-induced mucositis, xerostomia, amd healing of recalcitrant wounds in radiation-exposed regions, and that the multiple pathways mediate the beneficial effects, especially free radical scavenging, antioxidant, wound healing, anticancer, analgesic, anti-inflammatory, anabolic, anti-fatigue and anti-anaemic effects that add additional value to the use of honey as an adjunct in cancer therapy.

Conclusion: For the first time, this review addresses the underlying pharmacological related to the beneficial effects of honey in radiation-induced damage, and attempts at emphasizing the lacunae that need further studies for optimizing the use of honey as an adjunct in radiotherapy of HNC. The authors suggest that future studies should be directed at understanding the detailed molecular mechanisms responsible for the beneficial effects using validated cell culture and animal models of study. Large multicentric clinical trials with standardised honey also needed to understand the clinical use of honey.

Keywords: Honey, head and neck cancer, radiation, mucositis, xerostomia, mechanism of action.

Graphical Abstract
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Fitzmaurice, C.; Abate, D.; Abbasi, N.; Abbastabar, H.; Abd-Allah, F.; Abdel-Rahman, O.; Abdelalim, A.; Abdoli, A.; Abdollahpour, I.; Abdulle, A.S.M.; Abebe, N.D.; Abraha, H.N.; Abu-Raddad, L.J.; Abualhasan, A.; Adedeji, I.A.; Advani, S.M.; Afarideh, M.; Afshari, M.; Aghaali, M.; Agius, D.; Agrawal, S.; Ahmadi, A.; Ahmadian, E.; Ahmadpour, E.; Ahmed, M.B.; Akbari, M.E.; Akinyemiju, T.; Al-Aly, Z.; AlAbdulKader, A.M.; Alahdab, F.; Alam, T.; Alamene, G.M.; Alemnew, B.T.T.; Alene, K.A.; Alinia, C.; Alipour, V.; Aljunid, S.M.; Bakeshei, F.A.; Almadi, M.A.H.; Almasi-Hashiani, A.; Alsharif, U.; Alsowaidi, S.; Alvis-Guzman, N.; Amini, E.; Amini, S.; Amoako, Y.A.; Anbari, Z.; Anber, N.H.; Andrei, C.L.; Anjomshoa, M.; Ansari, F.; Ansariadi, A.; Appiah, S.C.Y.; Arab-Zozani, M.; Arabloo, J.; Arefi, Z.; Aremu, O.; Areri, H.A.; Artaman, A.; Asayesh, H.; Asfaw, E.T.; Ashagre, A.F.; Assadi, R.; Ataeinia, B.; Atalay, H.T.; Ataro, Z.; Atique, S.; Ausloos, M.; Avila-Burgos, L.; Avokpaho, E.F.G.A.; Awasthi, A.; Awoke, N.; Ayala Quintanilla, B.P.; Ayanore, M.A.; Ayele, H.T.; Babaee, E.; Bacha, U.; Badawi, A.; Bagherzadeh, M.; Bagli, E.; Balakrishnan, S.; Balouchi, A.; Bärnighausen, T.W.; Battista, R.J.; Behzadifar, M.; Behzadifar, M.; Bekele, B.B.; Belay, Y.B.; Belayneh, Y.M.; Berfield, K.K.S.; Berhane, A.; Bernabe, E.; Beuran, M.; Bhakta, N.; Bhattacharyya, K.; Biadgo, B.; Bijani, A.; Bin Sayeed, M.S.; Birungi, C.; Bisignano, C.; Bitew, H.; Bjørge, T.; Bleyer, A.; Bogale, K.A.; Bojia, H.A.; Borzì, A.M.; Bosetti, C.; Bou-Orm, I.R.; Brenner, H.; Brewer, J.D.; Briko, A.N.; Briko, N.I.; Bustamante-Teixeira, M.T.; Butt, Z.A.; Carreras, G.; Carrero, J.J.; Carvalho, F.; Castro, C.; Castro, F.; Catalá-López, F.; Cerin, E.; Chaiah, Y.; Chanie, W.F.; Chattu, V.K.; Chaturvedi, P.; Chauhan, N.S.; Chehrazi, M.; Chiang, P.P.; Chichiabellu, T.Y.; Chido-Amajuoyi, O.G.; Chimed-Ochir, O.; Choi, J.J.; Christopher, D.J.; Chu, D.T.; Constantin, M.M.; Costa, V.M.; Crocetti, E.; Crowe, C.S.; Curado, M.P.; Dahlawi, S.M.A.; Damiani, G.; Darwish, A.H.; Daryani, A.; das Neves, J.; Demeke, F.M.; Demis, A.B.; Demissie, B.W.; Demoz, G.T.; Denova-Gutiérrez, E.; Derakhshani, A.; Deribe, K.S.; Desai, R.; Desalegn, B.B.; Desta, M.; Dey, S.; Dharmaratne, S.D.; Dhimal, M.; Diaz, D.; Dinberu, M.T.T.; Djalalinia, S.; Doku, D.T.; Drake, T.M.; Dubey, M.; Dubljanin, E.; Duken, E.E.; Ebrahimi, H.; Effiong, A.; Eftekhari, A.; El Sayed, I.; Zaki, M.E.S.; El-Jaafary, S.I.; El-Khatib, Z.; Elemineh, D.A.; Elkout, H.; Ellenbogen, R.G.; Elsharkawy, A.; Emamian, M.H.; Endalew, D.A.; Endries, A.Y.; Eshrati, B.; Fadhil, I.; Fallah Omrani, V.; Faramarzi, M.; Farhangi, M.A.; Farioli, A.; Farzadfar, F.; Fentahun, N.; Fernandes, E.; Feyissa, G.T.; Filip, I.; Fischer, F.; Fisher, J.L.; Force, L.M.; Foroutan, M.; Freitas, M.; Fukumoto, T.; Futran, N.D.; Gallus, S.; Gankpe, F.G.; Gayesa, R.T.; Gebrehiwot, T.T.; Gebremeskel, G.G.; Gedefaw, G.A.; Gelaw, B.K.; Geta, B.; Getachew, S.; Gezae, K.E.; Ghafourifard, M.; Ghajar, A.; Ghashghaee, A.; Gholamian, A.; Gill, P.S.; Ginindza, T.T.G.; Girmay, A.; Gizaw, M.; Gomez, R.S.; Gopalani, S.V.; Gorini, G.; Goulart, B.N.G.; Grada, A.; Ribeiro Guerra, M.; Guimaraes, A.L.S.; Gupta, P.C.; Gupta, R.; Hadkhale, K.; Haj-Mirzaian, A.; Haj-Mirzaian, A.; Hamadeh, R.R.; Hamidi, S.; Hanfore, L.K.; Haro, J.M.; Hasankhani, M.; Hasanzadeh, A.; Hassen, H.Y.; Hay, R.J.; Hay, S.I.; Henok, A.; Henry, N.J.; Herteliu, C.; Hidru, H.D.; Hoang, C.L.; Hole, M.K.; Hoogar, P.; Horita, N.; Hosgood, H.D.; Hosseini, M.; Hosseinzadeh, M.; Hostiuc, M.; Hostiuc, S.; Househ, M.; Hussen, M.M.; Ileanu, B.; Ilic, M.D.; Innos, K.; Irvani, S.S.N.; Iseh, K.R.; Islam, S.M.S.; Islami, F.; Jafari Balalami, N.; Jafarinia, M.; Jahangiry, L.; Jahani, M.A.; Jahanmehr, N.; Jakovljevic, M.; James, S.L.; Javanbakht, M.; Jayaraman, S.; Jee, S.H.; Jenabi, E.; Jha, R.P.; Jonas, J.B.; Jonnagaddala, J.; Joo, T.; Jungari, S.B.; Jürisson, M.; Kabir, A.; Kamangar, F.; Karch, A.; Karimi, N.; Karimian, A.; Kasaeian, A.; Kasahun, G.G.; Kassa, B.; Kassa, T.D.; Kassaw, M.W.; Kaul, A.; Keiyoro, P.N.; Kelbore, A.G.; Kerbo, A.A.; Khader, Y.S.; Khalilarjmandi, M.; Khan, E.A.; Khan, G.; Khang, Y.H.; Khatab, K.; Khater, A.; Khayamzadeh, M.; Khazaee-Pool, M.; Khazaei, S.; Khoja, A.T.; Khosravi, M.H.; Khubchandani, J.; Kianipour, N.; Kim, D.; Kim, Y.J.; Kisa, A.; Kisa, S.; Kissimova-Skarbek, K.; Komaki, H.; Koyanagi, A.; Krohn, K.J.; Bicer, B.K.; Kugbey, N.; Kumar, V.; Kuupiel, D.; La Vecchia, C.; Lad, D.P.; Lake, E.A.; Lakew, A.M.; Lal, D.K.; Lami, F.H.; Lan, Q.; Lasrado, S.; Lauriola, P.; Lazarus, J.V.; Leigh, J.; Leshargie, C.T.; Liao, Y.; Limenih, M.A.; Listl, S.; Lopez, A.D.; Lopukhov, P.D.; Lunevicius, R.; Madadin, M.; Magdeldin, S.; El Razek, H.M.A.; Majeed, A.; Maleki, A.; Malekzadeh, R.; Manafi, A.; Manafi, N.; Manamo, W.A.; Mansourian, M.; Mansournia, M.A.; Mantovani, L.G.; Maroufizadeh, S.; Martini, S.M.S.; Mashamba-Thompson, T.P.; Massenburg, B.B.; Maswabi, M.T.; Mathur, M.R.; McAlinden, C.; McKee, M.; Meheretu, H.A.A.; Mehrotra, R.; Mehta, V.; Meier, T.; Melaku, Y.A.; Meles, G.G.; Meles, H.G.; Melese, A.; Melku, M.; Memiah, P.T.N.; Mendoza, W.; Menezes, R.G.; Merat, S.; Meretoja, T.J.; Mestrovic, T.; Miazgowski, B.; Miazgowski, T.; Mihretie, K.M.M.; Miller, T.R.; Mills, E.J.; Mir, S.M.; Mirzaei, H.; Mirzaei, H.R.; Mishra, R.; Moazen, B.; Mohammad, D.K.; Mohammad, K.A.; Mohammad, Y.; Darwesh, A.M.; Mohammadbeigi, A.; Mohammadi, H.; Mohammadi, M.; Mohammadian, M.; Mohammadian-Hafshejani, A.; Mohammadoo-Khorasani, M.; Mohammadpourhodki, R.; Mohammed, A.S.; Mohammed, J.A.; Mohammed, S.; Mohebi, F.; Mokdad, A.H.; Monasta, L.; Moodley, Y.; Moosazadeh, M.; Moossavi, M.; Moradi, G.; Moradi-Joo, M.; Moradi-Lakeh, M.; Moradpour, F.; Morawska, L.; Morgado-da-Costa, J.; Morisaki, N.; Morrison, S.D.; Mosapour, A.; Mousavi, S.M.; Muche, A.A.; Muhammed, O.S.S.; Musa, J.; Nabhan, A.F.; Naderi, M.; Nagarajan, A.J.; Nagel, G.; Nahvijou, A.; Naik, G.; Najafi, F.; Naldi, L.; Nam, H.S.; Nasiri, N.; Nazari, J.; Negoi, I.; Neupane, S.; Newcomb, P.A.; Nggada, H.A.; Ngunjiri, J.W.; Nguyen, C.T.; Nikniaz, L.; Ningrum, D.N.A.; Nirayo, Y.L.; Nixon, M.R.; Nnaji, C.A.; Nojomi, M.; Nosratnejad, S.; Shiadeh, M.N.; Obsa, M.S.; Ofori-Asenso, R.; Ogbo, F.A.; Oh, I.H.; Olagunju, A.T.; Olagunju, T.O.; Oluwasanu, M.M.; Omonisi, A.E.; Onwujekwe, O.E.; Oommen, A.M.; Oren, E.; Ortega-Altamirano, D.D.V.; Ota, E.; Otstavnov, S.S.; Owolabi, M.O.; P A, M.; Padubidri, J.R.; Pakhale, S.; Pakpour, A.H.; Pana, A.; Park, E.K.; Parsian, H.; Pashaei, T.; Patel, S.; Patil, S.T.; Pennini, A.; Pereira, D.M.; Piccinelli, C.; Pillay, J.D.; Pirestani, M.; Pishgar, F.; Postma, M.J.; Pourjafar, H.; Pourmalek, F.; Pourshams, A.; Prakash, S.; Prasad, N.; Qorbani, M.; Rabiee, M.; Rabiee, N.; Radfar, A.; Rafiei, A.; Rahim, F.; Rahimi, M.; Rahman, M.A.; Rajati, F.; Rana, S.M.; Raoofi, S.; Rath, G.K.; Rawaf, D.L.; Rawaf, S.; Reiner, R.C.; Renzaho, A.M.N.; Rezaei, N.; Rezapour, A.; Ribeiro, A.I.; Ribeiro, D.; Ronfani, L.; Roro, E.M.; Roshandel, G.; Rostami, A.; Saad, R.S.; Sabbagh, P.; Sabour, S.; Saddik, B.; Safiri, S.; Sahebkar, A.; Salahshoor, M.R.; Salehi, F.; Salem, H.; Salem, M.R.; Salimzadeh, H.; Salomon, J.A.; Samy, A.M.; Sanabria, J.; Santric Milicevic, M.M.; Sartorius, B.; Sarveazad, A.; Sathian, B.; Satpathy, M.; Savic, M.; Sawhney, M.; Sayyah, M.; Schneider, I.J.C.; Schöttker, B.; Sekerija, M.; Sepanlou, S.G.; Sepehrimanesh, M.; Seyedmousavi, S.; Shaahmadi, F.; Shabaninejad, H.; Shahbaz, M.; Shaikh, M.A.; Shamshirian, A.; Shamsizadeh, M.; Sharafi, H.; Sharafi, Z.; Sharif, M.; Sharifi, A.; Sharifi, H.; Sharma, R.; Sheikh, A.; Shirkoohi, R.; Shukla, S.R.; Si, S.; Siabani, S.; Silva, D.A.S.; Silveira, D.G.A.; Singh, A.; Singh, J.A.; Sisay, S.; Sitas, F.; Sobngwi, E.; Soofi, M.; Soriano, J.B.; Stathopoulou, V.; Sufiyan, M.B.; Tabarés-Seisdedos, R.; Tabuchi, T.; Takahashi, K.; Tamtaji, O.R.; Tarawneh, M.R.; Tassew, S.G.; Taymoori, P.; Tehrani-Banihashemi, A.; Temsah, M.H.; Temsah, O.; Tesfay, B.E.; Tesfay, F.H.; Teshale, M.Y.; Tessema, G.A.; Thapa, S.; Tlaye, K.G.; Topor-Madry, R.; Tovani-Palone, M.R.; Traini, E.; Tran, B.X.; Tran, K.B.; Tsadik, A.G.; Ullah, I.; Uthman, O.A.; Vacante, M.; Vaezi, M.; Varona Pérez, P.; Veisani, Y.; Vidale, S.; Violante, F.S.; Vlassov, V.; Vollset, S.E.; Vos, T.; Vosoughi, K.; Vu, G.T.; Vujcic, I.S.; Wabinga, H.; Wachamo, T.M.; Wagnew, F.S.; Waheed, Y.; Weldegebreal, F.; Weldesamuel, G.T.; Wijeratne, T.; Wondafrash, D.Z.; Wonde, T.E.; Wondmieneh, A.B.; Workie, H.M.; Yadav, R.; Yadegar, A.; Yadollahpour, A.; Yaseri, M.; Yazdi-Feyzabadi, V.; Yeshaneh, A.; Yimam, M.A.; Yimer, E.M.; Yisma, E.; Yonemoto, N.; Younis, M.Z.; Yousefi, B.; Yousefifard, M.; Yu, C.; Zabeh, E.; Zadnik, V.; Moghadam, T.Z.; Zaidi, Z.; Zamani, M.; Zandian, H.; Zangeneh, A.; Zaki, L.; Zendehdel, K.; Zenebe, Z.M.; Zewale, T.A.; Ziapour, A.; Zodpey, S.; Murray, C.J.L. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol., 2019, 5(12), 1749-1768.
[http://dx.doi.org/10.1001/jamaoncol.2019.2996] [PMID: 31560378]
[2]
Taibi, R.; Lleshi, A.; Barzan, L.; Fiorica, F.; Leghissa, M.; Vaccher, E.; De Paoli, P.; Franchin, G.; Berretta, M.; Tirelli, U. Head and neck cancer survivors patients and late effects related to oncologic treatment: update of literature. Eur. Rev. Med. Pharmacol. Sci., 2014, 18(10), 1473-1481.
[PMID: 24899605]
[3]
Ramsay, E.I.; Rao, S.; Madathil, L.; Hegde, S.K.; Baliga-Rao, M.P.; George, T.; Baliga, M.S. Honey in oral health and care: A mini review. J Oral Biosci, 2019, 61(1), 32-36.
[http://dx.doi.org/10.1016/j.job.2018.12.003] [PMID: 30929799]
[4]
Ahmed, S.; Sulaiman, S.A.; Baig, A.A.; Ibrahim, M.; Liaqat, S.; Fatima, S.; Jabeen, S.; Shamim, N.; Othman, N.H. Honey as a potential natural antioxidant medicine: an insight into its molecular mechanisms of action. Oxid. Med. Cell. Longev., 2018, 2018, 8367846.
[http://dx.doi.org/10.1155/2018/8367846] [PMID: 29492183]
[5]
Ahmed, S.; Sulaiman, S.A.; Othman, N.H. Oral administration of tualang and manuka honeys modulates breast cancer progression in sprague-dawley rats model. Evid. Based Complement. Alternat. Med., 2017, 2017, 5904361.
[http://dx.doi.org/10.1155/2017/5904361] [PMID: 28479926]
[6]
Sampath, K. K.P.; Bhowmik, D.; Chiranjib, Biswajit, Chandira, M.R. Medicinal uses and health benefits of honey: an overview. J. Chem. Pharm. Res., 2010, 2, 385-395.
[7]
Ezz, E-A. A.M.; Girgis, S.M.; Hegazy, E.M.; Abd, El-Khalek, A.B. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC Complement. Altern. Med., 2006, 6, 6.
[http://dx.doi.org/10.1186/1472-6882-6-6]
[8]
Ahmad, R.S.; Muhammad, B.H.; Saeed, F.; Waheed, M.; Tufail, T. Phytochemistry, metabolism and ethnomedical scenario of honey: A concurrent review. Int. J. Food Prop., 2017, 2, 254-269.
[http://dx.doi.org/10.1080/10942912.2017.1295257]
[9]
Hermosín, I.; Chicón, R.M.; Cabezudo, M.D. Free amino acid composition and botanical origin of honey. Food Chem., 2003, 83, 263-268.
[http://dx.doi.org/10.1016/S0308-8146(03)00089-X]
[10]
Alotibi, I.A.; Harakeh, S.M.; Al-Mamary, M.; Mariod, A.A.; Al-Jaouni, S.K.; Al-Masaud, S.; Alharbi, M.G.; Al-Hindi, R.R. Floral markers and biological activity of Saudi honey. Saudi J. Biol. Sci., 2018, 25(7), 1369-1374.
[http://dx.doi.org/10.1016/j.sjbs.2018.05.021] [PMID: 30505183]
[11]
Afrin, S.; Haneefa, S.M.; Fernandez-Cabezudo, M.J.; Giampieri, F.; Al-Ramadi, B.K.; Battino, M. Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review. Nutr. Res. Rev., 2020, 33(1), 50-76.
[http://dx.doi.org/10.1017/S0954422419000192] [PMID: 31791437]
[12]
Bansal, V.; Medhi, B.; Pandhi, P. Honey-a remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J (KUMJ), 2005, 3(3), 305-309.
[PMID: 18650599]
[13]
Sonis, S.T. Oral mucositis in head and neck cancer: risk, biology, and management. Am. Soc. Clin. Oncol. Educ. Book, 2013.
[http://dx.doi.org/10.14694/EdBook_AM.2013.33.e236] [PMID: 23714511]
[14]
Oronsky, B.; Goyal, S.; Kim, M.M.; Cabrales, P.; Lybeck, M.; Caroen, S.; Oronsky, N.; Burbano, E.; Carter, C.; Oronsky, A. A review of clinical radioprotection and chemoprotection for oral mucositis. Transl. Oncol., 2018, 11(3), 771-778.
[http://dx.doi.org/10.1016/j.tranon.2018.03.014] [PMID: 29698934]
[15]
Kusiak, A.; Jereczek-Fossa, B.A.; Cichońska, D.; Alterio, D. Oncological-therapy related oral mucositis as an interdisciplinary problem-literature review. Int. J. Environ. Res. Public Health, 2020, 17(7), 2464.
[http://dx.doi.org/10.3390/ijerph17072464] [PMID: 32260309]
[16]
Scully, C.; Sonis, S.; Diz, P.D. Oral mucositis. Oral Dis., 2006, 12(3), 229-241.
[http://dx.doi.org/10.1111/j.1601-0825.2006.01258.x] [PMID: 16700732]
[17]
Rodríguez-Caballero, A.; Torres-Lagares, D.; Robles-García, M.; Pachón-Ibáñez, J.; González-Padilla, D.; Gutiérrez-Pérez, J.L. Cancer treatment-induced oral mucositis: a critical review. Int. J. Oral Maxillofac. Surg., 2012, 41(2), 225-238.
[http://dx.doi.org/10.1016/j.ijom.2011.10.011] [PMID: 22071451]
[18]
Benyamin, R.; Trescot, A.M.; Datta, S.; Buenaventura, R.; Adlaka, R.; Sehgal, N.; Glaser, S.E.; Vallejo, R. Opioid complications and side effects. Pain Physician, 2008, 11(2)(Suppl.), S105-S120.
[PMID: 18443635]
[19]
Elsass, F.T. A sweet solution: the use of medical-grade honey on oral mucositis in the pediatric oncology patient. Wounds, 2017, 29(12), E115-E117.
[PMID: 29324426]
[20]
Howlader, D.; Singh, V.; Mohammad, S.; Gupta, S.; Pal, U.S.; Pal, M. Effect of topical application of pure honey in chemo-radiation-induced mucositis and its clinical benefits in improving quality of life in patients of oral squamous cell carcinoma. J. Maxillofac. Oral Surg., 2019, 18(1), 73-79.
[http://dx.doi.org/10.1007/s12663-017-1077-9] [PMID: 30728696]
[21]
Biswal, B.M.; Zakaria, A.; Ahmad, N.M. Topical application of honey in the management of radiation mucositis: a preliminary study. Support. Care Cancer, 2003, 11(4), 242-248.
[http://dx.doi.org/10.1007/s00520-003-0443-y] [PMID: 12673463]
[22]
Maiti, P.K.; Ray, A.; Mitra, T.N.; Jana, U.; Bhattacharya, J.; Ganguly, S. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J. Indian Med. Assoc., 2012, 110(7), 453-456.
[PMID: 23520669]
[23]
Jayachandran, S.; Balaji, N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J. Palliat. Care, 2012, 18(3), 190-195.
[http://dx.doi.org/10.4103/0973-1075.105689] [PMID: 23439942]
[24]
Abdulrhman, M.; Elbarbary, N.S.; Ahmed Amin, D.; Saeid Ebrahim, R. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr. Hematol. Oncol., 2012, 29(3), 285-292.
[http://dx.doi.org/10.3109/08880018.2012.669026] [PMID: 22475306]
[25]
Samdariya, S.; Lewis, S.; Kauser, H.; Ahmed, I.; Kumar, D. A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients. Indian J. Palliat. Care, 2015, 21(3), 268-273.
[http://dx.doi.org/10.4103/0973-1075.164892] [PMID: 26600693]
[26]
Kobya Bulut, H.; Güdücü Tüfekci, F. Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group. Complement. Ther. Med., 2016, 29, 132-140.
[http://dx.doi.org/10.1016/j.ctim.2016.09.018] [PMID: 27912937]
[27]
Rao, S.; Hegde, S.K.; Rao, P.; Dinkar, C.; Thilakchand, K.R.; George, T.; Baliga-Rao, M.P.; Palatty, P.L.; Baliga, M.S. Honey mitigates radiation-induced oral mucositis in head and neck cancer patients without affecting the tumor response. Foods, 2017, 6(9), 77.
[http://dx.doi.org/10.3390/foods6090077] [PMID: 28878156]
[28]
Al, J. S.K.; Al, Muhayawi, M.S.; Hussein, A.; Elfiki, I.; Al-Raddadi, R.; Al, Muhayawi, S.M.; Almasaudi, S.; Kamal, M.A.; Harakeh, S. Effects of honey on oral mucositis among pediatric cancer patients undergoing chemo/radiotherapy treatment at king abdulaziz university hospital in Jeddah, Kingdom of Saudi Arabia. Evid. Based Complement. Alternat. Med., 2017, 5861024
[http://dx.doi.org/10.1155/2017/5861024]
[29]
Xu, J.L.; Xia, R.; Sun, Z.H.; Sun, L.; Min, X.; Liu, C.; Zhang, H.; Zhu, Y.M. Effects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis of randomized controlled trials. Int. J. Oral Maxillofac. Surg., 2016, 45(12), 1618-1625.
[http://dx.doi.org/10.1016/j.ijom.2016.04.023] [PMID: 27600797]
[30]
Co, J.L.; Mejia, M.B.; Que, J.C.; Dizon, J.M. Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature. Head Neck, 2016, 38(7), 1119-1128.
[http://dx.doi.org/10.1002/hed.24431] [PMID: 27028991]
[31]
Sonis, S.T. Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol., 2009, 45(12), 1015-1020.
[http://dx.doi.org/10.1016/j.oraloncology.2009.08.006] [PMID: 19828360]
[32]
Ma, S.J.; Rivers, C.I.; Serra, L.M.; Singh, A.K. Long-term outcomes of interventions for radiation-induced xerostomia: A review. World J. Clin. Oncol., 2019, 10(1), 1-13.
[http://dx.doi.org/10.5306/wjco.v10.i1.1] [PMID: 30627521]
[33]
Acauan, M.D.; Figueiredo, M.A.; Cherubini, K.; Gomes, A.P.; Salum, F.G. Radiotherapy-induced salivary dysfunction: Structural changes, pathogenetic mechanisms and therapies. Arch. Oral Biol., 2015, 60(12), 1802-1810.
[http://dx.doi.org/10.1016/j.archoralbio.2015.09.014] [PMID: 26454716]
[34]
Charalambous, A.; Lambrinou, E.; Katodritis, N.; Vomvas, D.; Raftopoulos, V.; Georgiou, M.; Paikousis, L.; Charalambous, M. The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial. Eur. J. Oncol. Nurs., 2017, 27, 1-8.
[http://dx.doi.org/10.1016/j.ejon.2017.01.001] [PMID: 28279391]
[35]
Sela, M.O.; Shapira, L.; Grizim, I.; Lewinstein, I.; Steinberg, D.; Gedalia, I.; Grobler, S.R. Effects of honey consumption on enamel microhardness in normal versus xerostomic patients. J. Oral Rehabil., 1998, 25(8), 630-634.
[http://dx.doi.org/10.1046/j.1365-2842.1998.00274.x] [PMID: 9781867]
[36]
Blair, S.E.; Cokcetin, N.N.; Harry, E.J.; Carter, D.A. The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis. Eur. J. Clin. Microbiol. Infect. Dis., 2009, 28(10), 1199-1208.
[http://dx.doi.org/10.1007/s10096-009-0763-z] [PMID: 19513768]
[37]
Mohapatra, D.P.; Thakur, V.; Brar, S.K. Antibacterial efficacy of raw and processed honey. Biotechnol. Res. Int., 2011, 2011, 917505.
[http://dx.doi.org/10.4061/2011/917505] [PMID: 21350671]
[38]
Alandejani, T.; Marsan, J.; Ferris, W.; Slinger, R.; Chan, F. Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngol. Head Neck Surg., 2009, 141(1), 114-118.
[http://dx.doi.org/10.1016/j.otohns.2009.01.005] [PMID: 19559969]
[39]
Al-Jabri, A.A.; Al-Hosni, S.A.; Nzeako, B.C.; Al-Mahrooqi, Z.H.; Nsanze, H. Antibacterial activity of Omani honey alone and in combination with gentamicin. Saudi Med. J., 2005, 26(5), 767-771.
[PMID: 15951867]
[40]
Maddocks, S.E.; Lopez, M.S.; Rowlands, R.S.; Cooper, R.A. Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology (Reading), 2012, 158(Pt 3), 781-790.
[http://dx.doi.org/10.1099/mic.0.053959-0] [PMID: 22294681]
[41]
Maddocks, S.E.; Jenkins, R.E.; Rowlands, R.S.; Purdy, K.J.; Cooper, R.A. Manuka honey inhibits adhesion and invasion of medically important wound bacteria in vitro . Future Microbiol., 2013, 8(12), 1523-1536.
[http://dx.doi.org/10.2217/fmb.13.126] [PMID: 24266353]
[42]
Majtan, J.; Bohova, J.; Horniackova, M.; Klaudiny, J.; Majtan, V. Anti-biofilm effects of honey against wound pathogens Proteus mirabilis and Enterobacter cloacae. Phytother. Res., 2014, 28(1), 69-75.
[http://dx.doi.org/10.1002/ptr.4957] [PMID: 23494861]
[43]
Steinberg, D.; Kaine, G.; Gedalia, I. Antibacterial effect of propolis and honey on oral bacteria. Am. J. Dent., 1996, 9(6), 236-239.
[PMID: 9545875]
[44]
Schmidlin, P.R.; English, H.; Duncan, W.; Belibasakis, G.N.; Thurnheer, T. Antibacterial potential of Manuka honey against three oral bacteria in vitro . Swiss Dent. J., 2014, 124(9), 922-924.
[PMID: 25253413]
[45]
Nassar, H.M.; Li, M.; Gregory, R.L. Effect of honey on Streptococcus mutans growth and biofilm formation. Appl. Environ. Microbiol., 2012, 78(2), 536-540.
[http://dx.doi.org/10.1128/AEM.05538-11] [PMID: 22038612]
[46]
Aparna, S.; Srirangarajan, S.; Malgi, V.; Setlur, K.P.; Shashidhar, R.; Setty, S.; Thakur, S. A comparative evaluation of the antibacterial efficacy of honey in vitro and antiplaque efficacy in a 4-day plaque regrowth model in vivo: preliminary results. J. Periodontol., 2012, 83(9), 1116-1121.
[http://dx.doi.org/10.1902/jop.2012.110461] [PMID: 22309178]
[47]
Ahmadi-Motamayel, F.; Hendi, S.S.; Alikhani, M.Y.; Khamverdi, Z. Antibacterial activity of honey on cariogenic bacteria. J. Dent. (Tehran), 2013, 10(1), 10-15.
[PMID: 23724198]
[48]
Mathai, K.; Anand, S.; Aravind, A.; Dinatius, P.; Krishnan, A.V.; Mathai, M. Antimicrobial effect of ginger, garlic, honey, and lemon extracts on Streptococcus mutans. J. Contemp. Dent. Pract., 2017, 18(11), 1004-1008.
[http://dx.doi.org/10.5005/jp-journals-10024-2165] [PMID: 29109311]
[49]
Safii, S.H.; Tompkins, G.R.; Duncan, W.J. Periodontal application of manuka honey: Antimicrobial and demineralising effects in vitro . Int. J. Dent., 2017, 2017, 9874535.
[http://dx.doi.org/10.1155/2017/9874535] [PMID: 28392803]
[50]
Badet, C.; Quero, F. The in vitro effect of manuka honeys on growth and adherence of oral bacteria. Anaerobe, 2011, 17(1), 19-22.
[http://dx.doi.org/10.1016/j.anaerobe.2010.12.007] [PMID: 21195787]
[51]
Atwa, A.D.; AbuShahba, R.Y.; Mostafa, M.; Hashem, M.I. Effect of honey in preventing gingivitis and dental caries in patients undergoing orthodontic treatment. Saudi Dent. J., 2014, 26(3), 108-114.
[http://dx.doi.org/10.1016/j.sdentj.2014.03.001] [PMID: 25057231]
[52]
Singhal, R.; Siddibhavi, M.; Sankeshwari, R.; Patil, P.; Jalihal, S.; Ankola, A. Effectiveness of three mouthwashes - Manuka honey, Raw honey, and Chlorhexidine on plaque and gingival scores of 12-15-year-old school children: A randomized controlled field trial. J. Indian Soc. Periodontol., 2018, 22(1), 34-39.
[http://dx.doi.org/10.4103/jisp.jisp_356_17] [PMID: 29568170]
[53]
Rupesh, S.; Winnier, J.J.; Nayak, U.A.; Rao, A.P.; Reddy, N.V.; Peter, J. Evaluation of the effects of manuka honey on salivary levels of mutans streptococci in children: a pilot study. J. Indian Soc. Pedod. Prev. Dent., 2014, 32(3), 212-219.
[http://dx.doi.org/10.4103/0970-4388.135827] [PMID: 25001440]
[54]
Abdelmegid, F.; Al-Agamy, M.; Alwohaibi, A.; Ka’abi, H.; Salama, F. Effect of honey and green tea solutions on Streptococcus mutans. J. Clin. Pediatr. Dent., 2015, 39(5), 435-441.
[http://dx.doi.org/10.17796/1053-4628-39.5.435] [PMID: 26551366]
[55]
Beena, J.P.; Sahoo, P.; Konde, S.; Raj, N.S.; Kumar, N.C.; Agarwal, M. Manuka honey: A potent cariostatic agent- an in vitro study. Int. J. Clin. Pediatr. Dent., 2018, 11(2), 105-109.
[http://dx.doi.org/10.5005/jp-journals-10005-1494] [PMID: 29991862]
[56]
Henriques, A.F.; Jenkins, R.E.; Burton, N.F.; Cooper, R.A. The effect of manuka honey on the structure of Pseudomonas aeruginosa. Eur. J. Clin. Microbiol. Infect. Dis., 2011, 30(2), 167-171.
[http://dx.doi.org/10.1007/s10096-010-1065-1] [PMID: 20936493]
[57]
Al-Waili, N.S.; Akmal, M.; Al-Waili, F.S.; Saloom, K.Y.; Ali, A. The antimicrobial potential of honey from United Arab Emirates on some microbial isolates. Med. Sci. Monit., 2005, 11(12), BR433-BR438.
[PMID: 16319779]
[58]
Al-Waili, N.S. Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva. J. Med. Food, 2004, 7(2), 210-222.
[http://dx.doi.org/10.1089/1096620041224139] [PMID: 15298770]
[59]
Alnaqdy, A.; Al-Jabri, A.; Al Mahrooqi, Z.; Nzeako, B.; Nsanze, H. Inhibition effect of honey on the adherence of Salmonella to intestinal epithelial cells in vitro . Int. J. Food Microbiol., 2005, 103(3), 347-351.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2004.11.042] [PMID: 16099316]
[60]
Molan, P.C. The potential of honey to promote oral wellness. Gen. Dent., 2001, 49(6), 584-589.
[PMID: 12024746]
[61]
Gu, Q.; Wang, D.; Cui, C.; Gao, Y.; Xia, G.; Cui, X. Effects of radiation on wound healing. J. Environ. Pathol. Toxicol. Oncol., 1998, 17(2), 117-123.
[PMID: 9546747]
[62]
Burlando, B.; Cornara, L. Honey in dermatology and skin care: a review. J. Cosmet. Dermatol., 2013, 12(4), 306-313.
[http://dx.doi.org/10.1111/jocd.12058] [PMID: 24305429]
[63]
Vandamme, L.; Heyneman, A.; Hoeksema, H.; Verbelen, J.; Monstrey, S. Honey in modern wound care: a systematic review. Burns, 2013, 39(8), 1514-1525.
[http://dx.doi.org/10.1016/j.burns.2013.06.014] [PMID: 23896128]
[64]
Jull, A.B.; Walker, N.; Deshpande, S. Honey as a topical treatment for wounds. Cochrane Database Syst. Rev., 2013, 2(2), CD005083.
[http://dx.doi.org/10.1002/14651858.CD005083.pub3] [PMID: 23450557]
[65]
Song, J.J.; Salcido, R. Use of honey in wound care: an update. Adv. Skin Wound Care, 2011, 24(1), 40-44.
[http://dx.doi.org/10.1097/01.ASW.0000392731.34723.06] [PMID: 21150765]
[66]
Saikaly, S.K.; Khachemoune, A. Honey and wound healing: An update. Am. J. Clin. Dermatol., 2017, 18(2), 237-251.
[http://dx.doi.org/10.1007/s40257-016-0247-8] [PMID: 28063093]
[67]
Takzaree, N.; Hassanzadeh, G.; Rouini, M.R.; Manayi, A.; Hadjiakhondi, A.; Majidi Zolbin, M. Evaluation of the effects of local application of thyme honey in open cutaneous wound healing. Iran. J. Public Health, 2017, 46(4), 545-551.
[PMID: 28540272]
[68]
Niaz, K.; Maqbool, F.; Bahadar, H.; Abdollahi, M. Health benefits of manuka honey as an essential constituent for tissue regeneration. Curr. Drug Metab., 2017, 18(10), 881-892.
[PMID: 28901255]
[69]
Martinotti, S.; Bucekova, M.; Majtan, J.; Ranzato, E. Honey: an effective regenerative medicine product in wound management. Curr. Med. Chem., 26(27), 5230-5240.
[PMID: 29745320]
[70]
Cutting, K.F. Honey and contemporary wound care: an overview. Ostomy Wound Manage., 2007, 53(11), 49-54.
[PMID: 18057446]
[71]
Gethin, G.; Cowman, S. Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: an RCT. J. Wound Care, 2008, 17(6), 241-244, 246-247.
[http://dx.doi.org/10.12968/jowc.2008.17.6.29583] [PMID: 18666717]
[72]
Armstrong, D.G. Manuka honey improved wound healing in patients with sloughy venous leg ulcers. Evid. Based Med., 2009, 14(5), 148.
[http://dx.doi.org/10.1136/ebm.14.5.148] [PMID: 19794023]
[73]
Robson, V.; Cooper, R. Using leptospermum honey to manage wounds impaired by radiotherapy: a case series. Ostomy Wound Manage., 2009, 55(1), 38-47.
[PMID: 19174588]
[74]
Rothmeier, N.; Abu-Jawad, J.; Arnolds, J.; Arweiler-Harbeck, D.; Dominas, N.; Stein, R.; Zander, S.; Lang, S.; Mattheis, S. The treatment of chronic wounds in the head and neck area after radiotherapy with medical honey. Laryngorhinootologie, 2014, 93(9), 612-618.
[PMID: 25152972]
[75]
Langius, J.A.; Bakker, S.; Rietveld, D.H.; Kruizenga, H.M.; Langendijk, J.A.; Weijs, P.J.; Leemans, C.R. Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy. Br. J. Cancer, 2013, 109(5), 1093-1099.
[http://dx.doi.org/10.1038/bjc.2013.458] [PMID: 23928661]
[76]
Motallebnejad, M.; Akram, S.; Moghadamnia, A.; Moulana, Z.; Omidi, S. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J. Contemp. Dent. Pract., 2008, 9(3), 40-47.
[http://dx.doi.org/10.5005/jcdp-9-3-40] [PMID: 18335118]
[77]
Khanjani Pour-Fard-Pachekenari, A.; Rahmani, A.; Ghahramanian, A.; Asghari Jafarabadi, M.; Onyeka, T.C.; Davoodi, A. The effect of an oral care protocol and honey mouthwash on mucositis in acute myeloid leukemia patients undergoing chemotherapy: a single-blind clinical trial. Clin. Oral Investig., 2019, 23(4), 1811-1821.
[http://dx.doi.org/10.1007/s00784-018-2621-9] [PMID: 30206708]
[78]
Ramasamy, V.; Binti Mat Lazim, N.; Abdullah, B.; Singh, A. Effects of tualang honey on cancer related fatigue: A multicenter open-label trialof H&N cancer patients. Gulf J. Oncolog., 2019, 1(30), 43-51.
[PMID: 31242981]
[79]
Haydak, M.H.; Palmer, L.S.; Tanquary, M.C. The role of honey in the prevention and cure of nutritional anemia in rats. J. Pediatr., 1942, 21, 763-768.
[http://dx.doi.org/10.1016/S0022-3476(42)80064-5]
[80]
Fihri, A.F.; Al-Waili, N.S.; El-Haskoury, R.; Bakour, M.; Amarti, A.; Ansari, M.J.; Lyoussi, B. Protective effect of morocco carob honey against lead-induced anemia and hepato-renal toxicity. Cell. Physiol. Biochem., 2016, 39(1), 115-122.
[http://dx.doi.org/10.1159/000445610] [PMID: 27322825]
[81]
Yahyapour, R.; Amini, P.; Rezapour, S.; Cheki, M.; Rezaeyan, A.; Farhood, B.; Shabeeb, D.; Musa, A.E.; Fallah, H.; Najafi, M. Radiation-induced inflammation and autoimmune diseases. Mil. Med. Res., 2018, 5(1), 9.
[http://dx.doi.org/10.1186/s40779-018-0156-7] [PMID: 29554942]
[82]
Yahyapour, R.; Amini, P.; Rezapoor, S.; Rezaeyan, A.; Farhood, B.; Cheki, M.; Fallah, H.; Najafi, M. Targeting of inflammation for radiation protection and mitigation. Curr. Mol. Pharmacol., 2018, 11(3), 203-210.
[http://dx.doi.org/10.2174/1874467210666171108165641] [PMID: 29119941]
[83]
Gheldof, N.; Engeseth, N.J. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J. Agric. Food Chem., 2002, 50(10), 3050-3055.
[http://dx.doi.org/10.1021/jf0114637] [PMID: 11982440]
[84]
Zhou, J.; Li, P.; Cheng, N.; Gao, H.; Wang, B.; Wei, Y.; Cao, W. Protective effects of buckwheat honey on DNA damage induced by hydroxyl radicals. Food Chem. Toxicol., 2012, 50(8), 2766-2773.
[http://dx.doi.org/10.1016/j.fct.2012.05.046] [PMID: 22683488]
[85]
Alvarez-Suarez, J.M.; Giampieri, F.; Battino, M. Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases. Curr. Med. Chem., 2013, 20(5), 621-638.
[http://dx.doi.org/10.2174/092986713804999358] [PMID: 23298140]
[86]
Barui, A.; Banerjee, P.; Patra, R.; Das, R.K.; Dhara, S.; Dutta, P.K.; Chatterjee, J. Swept-source optical coherence tomography of lower limb wound healing with histopathological correlation. J. Biomed. Opt., 2011, 16(2), 026010.
[http://dx.doi.org/10.1117/1.3535593] [PMID: 21361694]
[87]
Ranzato, E.; Martinotti, S.; Burlando, B. Epithelial mesenchymal transition traits in honey-driven keratinocyte wound healing: comparison among different honeys. Wound Repair Regen., 2012, 20(5), 778-785.
[http://dx.doi.org/10.1111/j.1524-475X.2012.00825.x] [PMID: 22882448]
[88]
Yilmaz, N.; Nisbet, O.; Nisbet, C.; Ceylan, G.; Hoşgör, F.; Dede, Ö.D. Biochemical evaluation of the therapeutic effectiveness of honey in oral mucosal ulcers. Bosn. J. Basic Med. Sci., 2009, 9(4), 290-295.
[http://dx.doi.org/10.17305/bjbms.2009.2781] [PMID: 20001994]
[89]
Chamani, G.; Zarei, M.R.; Mehrabani, M.; Mehdavinezhad, A.; Vahabian, M.; Ahmadi-Motamayel, F. Evaluation of honey as a topical therapy for intraoral wound healing in rats. Wounds, 2017, 29(3), 80-86.
[PMID: 28054920]
[90]
Wen, C.T.; Hussein, S.Z.; Abdullah, S.; Karim, N.A.; Makpol, S.; Mohd Yusof, Y.A. Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. Asian Pac. J. Cancer Prev., 2012, 13(4), 1605-1610.
[http://dx.doi.org/10.7314/APJCP.2012.13.4.1605] [PMID: 22799375]
[91]
Samarghandian, S.; Afshari, J.T.; Davoodi, S. Honey induces apoptosis in renal cell carcinoma. Pharmacogn. Mag., 2011, 7(25), 46-52.
[http://dx.doi.org/10.4103/0973-1296.75901] [PMID: 21472079]
[92]
Ghashm, A.A.; Othman, N.H.; Khattak, M.N.; Ismail, N.M.; Saini, R. Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. BMC Complement. Altern. Med., 2010, 10, 49.
[http://dx.doi.org/10.1186/1472-6882-10-49] [PMID: 20840769]
[93]
Swellam, T.; Miyanaga, N.; Onozawa, M.; Hattori, K.; Kawai, K.; Shimazui, T.; Akaza, H. Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. Int. J. Urol., 2003, 10(4), 213-219.
[http://dx.doi.org/10.1046/j.0919-8172.2003.00602.x] [PMID: 12657101]
[94]
Mishima, S.; Ono, Y.; Araki, Y.; Akao, Y.; Nozawa, Y. Two related cinnamic Acid derivatives from Brazilian honey bee propolis, baccharin and drupanin, induce growth inhibition in allografted sarcoma S-180 in mice. Biol. Pharm. Bull., 2005, 28(6), 1025-1030.
[http://dx.doi.org/10.1248/bpb.28.1025] [PMID: 15930739]
[95]
Attia, W.Y.; Gabry, M.S.; El-Shaikh, K.A.; Othman, G.A. The anti-tumor effect of bee honey in Ehrlich ascite tumor model of mice is coincided with stimulation of the immune cells. Egypt. J. Immunol., 2008, 15(2), 169-183.
[PMID: 20306700]
[96]
Tomasin, R.; de Andrade, R.S.; Gomes-Marcondes, M.C. Oral administration of Aloe vera (L.) Burm. f. (xanthorrhoeaceae) and honey improves the host body composition and modulates proteolysis through reduction of tumor progression and oxidative stress in rats. J. Med. Food, 2015, 18(10), 1128-1135.
[http://dx.doi.org/10.1089/jmf.2014.0129] [PMID: 25856497]
[97]
Alizadeh, A.M.; Afrouzan, H.; Dinparast-Djadid, N.; Sawaya, A.C.; Azizian, S.; Hemmati, H.R.; Mohagheghi, M.A.; Erfani, S. Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch. Iran Med., 2015, 18(1), 18-23.
[PMID: 25556381]
[98]
Saiful Yazan, L.; Muhamad Zali, M.F.; Mohd Ali, R.; Zainal, N.A.; Esa, N.; Sapuan, S.; Ong, Y.S.; Tor, Y.S.; Gopalsamy, B.; Voon, F.L.; Syed Alwi, S.S. Chemopreventive properties and toxicity of kelulut honey in sprague dawley rats induced with azoxymethane. BioMed Res. Int., 2016, 2016, 4036926.
[http://dx.doi.org/10.1155/2016/4036926] [PMID: 27525267]
[99]
Muhammad, A.; Odunola, O.A.; Gbadegesin, M.A.; Adegoke, A.M.; Olugbami, J.O.; Uche, N.S. Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats. Nat. Prod. Res., 2015, 29(4), 321-326.
[http://dx.doi.org/10.1080/14786419.2014.940945] [PMID: 25105348]
[100]
Ahmad, I.; Jimenez, H.; Yaacob, N.S.; Yusuf, N. Tualang honey protects keratinocytes from ultraviolet radiation-induced inflammation and DNA damage. Photochem. Photobiol., 2012, 88(5), 1198-1204.
[http://dx.doi.org/10.1111/j.1751-1097.2012.01100.x] [PMID: 22276569]
[101]
Cheng, N.; Wang, Y.; Cao, W. The protective effect of whole honey and phenolic extract on oxidative DNA damage in mice lymphocytes using comet assay. Plant Foods Hum. Nutr., 2017, 72(4), 388-395.
[http://dx.doi.org/10.1007/s11130-017-0634-1] [PMID: 28929426]
[102]
Cheng, N.; Wu, L.; Zheng, J.; Cao, W. Buckwheat honey attenuates carbon tetrachloride-induced liver and DNA damage in mice. Evid. Based Complement. Alternat. Med., 2015, 2015, 987385.
[http://dx.doi.org/10.1155/2015/987385] [PMID: 26508989]
[103]
Alleva, R.; Manzella, N.; Gaetani, S.; Ciarapica, V.; Bracci, M.; Caboni, M.F.; Pasini, F.; Monaco, F.; Amati, M.; Borghi, B.; Tomasetti, M. Organic honey supplementation reverses pesticide-induced genotoxicity by modulating DNA damage response. Mol. Nutr. Food Res., 2016, 60(10), 2243-2255.
[http://dx.doi.org/10.1002/mnfr.201600005] [PMID: 27129605]
[104]
Mabrouk, G.M.; Moselhy, S.S.; Zohny, S.F.; Ali, E.M.; Helal, T.E.; Amin, A.A.; Khalifa, A.A. Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats. J. Exp. Clin. Cancer Res., 2002, 21(3), 341-346.
[PMID: 12385575]
[105]
Yazbeck, V.Y.; Villaruz, L.; Haley, M.; Socinski, M.A. Management of normal tissue toxicity associated with chemoradiation (primary skin, esophagus, and lung). Cancer J., 2013, 19(3), 231-237.
[http://dx.doi.org/10.1097/PPO.0b013e31829453fb] [PMID: 23708070]
[106]
Moolenaar, M.; Poorter, R.L.; van der Toorn, P.P.; Lenderink, A.W.; Poortmans, P.; Egberts, A.C. The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients. Acta Oncol., 2006, 45(5), 623-624.
[http://dx.doi.org/10.1080/02841860600781799] [PMID: 16864180]
[107]
Fogh, S.E.; Deshmukh, S.; Berk, L.B.; Dueck, A.C.; Roof, K.; Yacoub, S.; Gergel, T.; Stephans, K.; Rimner, A.; DeNittis, A.; Pablo, J.; Rineer, J.; Williams, T.M.; Bruner, D. A randomized phase 2 trial of prophylactic manuka honey for the reduction of chemoradiation therapy-induced esophagitis during the treatment of lung cancer: Results of NRG oncology RTOG 1012. Int. J. Radiat. Oncol. Biol. Phys., 2017, 97(4), 786-796.
[http://dx.doi.org/10.1016/j.ijrobp.2016.11.022] [PMID: 28244415]
[108]
Azim, M.K.; Perveen, H.; Mesaik, M.A.; Simjee, S.U. Antinociceptive activity of natural honey in thermal-nociception models in mice. Phytother. Res., 2007, 21(2), 194-197.
[http://dx.doi.org/10.1002/ptr.2049] [PMID: 17160970]
[109]
Gunduz, A.; Eraydin, I.; Turkmen, S.; Kalkan, O.F.; Turedi, S.; Eryigit, U.; Ayar, A. Analgesic effects of mad honey (grayanotoxin) in mice models of acute pain and painful diabetic neuropathy. Hum. Exp. Toxicol., 2014, 33(2), 130-135.
[http://dx.doi.org/10.1177/0960327113482693] [PMID: 23584354]
[110]
Owoyele, B.V.; Oladejo, R.O.; Ajomale, K.; Ahmed, R.O.; Mustapha, A. Analgesic and anti-inflammatory effects of honey: the involvement of autonomic receptors. Metab. Brain Dis., 2014, 29(1), 167-173.
[http://dx.doi.org/10.1007/s11011-013-9458-3] [PMID: 24318481]
[111]
van, den, Berg, A.J.; van, den, Worm, E.; van, Ufford, H.C.; Halkes, S.B.; Hoekstra, M.J.; Beukelman, C.J. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J. Wound Care, 2008, 17, 172-174, 176-178.
[http://dx.doi.org/10.12968/jowc.2008.17.4.28839]
[112]
Candiracci, M.; Piatti, E.; Dominguez-Barragán, M.; García-Antrás, D.; Morgado, B.; Ruano, D.; Gutiérrez, J.F.; Parrado, J.; Castaño, A. Anti-inflammatory activity of a honey flavonoid extract on lipopolysaccharide-activated N13 microglial cells. J. Agric. Food Chem., 2012, 60(50), 12304-12311.
[http://dx.doi.org/10.1021/jf302468h] [PMID: 23176387]
[113]
Ghazali, W.S.; Romli, A.C.; Mohamed, M. Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial. BMC Complement. Altern. Med., 2017, 17(1), 175.
[http://dx.doi.org/10.1186/s12906-017-1703-6] [PMID: 28351393]
[114]
Geißler, K.; Schulze, M.; Inhestern, J.; Meißner, W.; Guntinas-Lichius, O. The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study. PLoS One, 2020, 15(2), e0228481.
[http://dx.doi.org/10.1371/journal.pone.0228481] [PMID: 32040956]
[115]
Chepulis, L.; Starkey, N. The long-term effects of feeding honey compared with sucrose and a sugar-free diet on weight gain, lipid profiles, and DEXA measurements in rats. J. Food Sci., 2008, 73(1), H1-H7.
[http://dx.doi.org/10.1111/j.1750-3841.2007.00592.x] [PMID: 18211352]
[116]
Ajibola, A.; Chamunorwa, J.P.; Erlwanger, K.H. Comparative effects of honey and sugar on the morphometry of viscera in growing Sprague-Dawley rats (Rattusnorvegicus). Book of Abstract of 31st Scientific Conference: 7–9 September 2011., Sokoto: Physiological Society of Nigeria (PSN)2011, p. 9.
[117]
Ajibola, A.; Chamunorwa, J.P.; Erlwanger, K.H. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutr. Metab. (Lond.), 2012, 9(1), 61.
[http://dx.doi.org/10.1186/1743-7075-9-61] [PMID: 22716101]
[118]
Ajibola, A.; Chamunorwa, J.P.; Erlwanger, K.H. Comparative effect of cane syrup and natural honey on abdominal viscera of growing male and female rats. Indian J. Exp. Biol., 2013, 51(4), 303-312.
[PMID: 24195350]
[119]
Onesti, J.K.; Guttridge, D.C. Inflammation based regulation of cancer cachexia. BioMed Res. Int., 2014, 2014, 168407.
[http://dx.doi.org/10.1155/2014/168407] [PMID: 24877061]
[120]
Laine, A.; Iyengar, P.; Pandita, T.K. The role of inflammatory pathways in cancer-associated cachexia and radiation resistance. Mol. Cancer Res., 2013, 11(9), 967-972.
[http://dx.doi.org/10.1158/1541-7786.MCR-13-0189] [PMID: 23788634]
[121]
Benhanifia, M.B.; Boukraâ, L.; Hammoudi, S.M.; Sulaiman, S.A.; Manivannan, L. Recent patents on topical application of honey in wound and burn management. Recent Pat. Inflamm. Allergy Drug Discov., 2011, 5(1), 81-86.
[http://dx.doi.org/10.2174/187221311794474847] [PMID: 21171951]
[122]
Shah, A.; Amini-Nik, S. The role of phytochemicals in the inflammatory phase of wound healing. Int. J. Mol. Sci., 2017, 18(5), 18.
[http://dx.doi.org/10.3390/ijms18051068] [PMID: 28509885]

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